JACC：口服氟喹诺酮会增加主动脉夹层风险

2018-09-19 MedSci MedSci原创

既往研究显示氟喹诺酮治疗可能会增加胶原疾病、主动脉瘤与夹层（AA/AD）的发病风险。本研究的目的旨在通过一个大型国家行政数据库的案例交叉分析来评估这种相关性。本研究共纳入了2001-2011年1213例住院的AA/AD病人，分析结果发现，暴露于氟喹诺酮的概率在危险期（AA/AD事件发生前60天）比对照期（AA/AD事件发生前60-180天中的任意60天）要更高（1.6% vs. 0.6%； [OR

既往研究显示氟喹诺酮治疗可能会增加胶原疾病、主动脉瘤与夹层（AA/AD）的发病风险。本研究的目的旨在通过一个大型国家行政数据库的案例交叉分析来评估这种相关性。

本研究共纳入了2001-2011年1213例住院的AA/AD病人，分析结果发现，暴露于氟喹诺酮的概率在危险期（AA/AD事件发生前60天）比对照期（AA/AD事件发生前60-180天中的任意60天）要更高（1.6% vs. 0.6%； [OR]： 2.71； 95% [CI]： 1.14 - 6.46），在经其他感染或药物因素调整后分析发现，这种风险依旧存在（OR： 2.05； 95% CI： 1.13 - 3.71）。另外，延长暴露于氟喹诺酮的时间会进一步增加AA/AD的发病风险。

研究结果显示，服用氟喹诺酮与主动脉瘤和主动脉夹层发病风险的增加是呈相关性的。

原始出处：

Chienc C et al.Oral Fluoroquinolone and the Risk of Aortic Dissection.JACC.2018 Sep.

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2019-07-21 hbwxf

#JACC#

62 0
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2019-08-27 sjzlzc007

#喹诺酮#

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2018-09-21 12498568m50暂无昵称

#ACC#

66 0
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2018-09-21 circumcision

#主动脉#

68 0
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2018-09-21 mhzhuang@stu.e

#动脉夹层#

75 0
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2018-09-21 doctorzheng

#氟喹诺酮#

78 0
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2018-09-19 清风拂面

谢谢分享学习

117 0
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2018-09-19 smartxiuxiu

有点意思

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