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[GetTopicListResponse(id=2160133, encodeId=a4df21601335b, content=<a href='/topic/show?id=574b106e0569' target=_blank style='color:#2F92EE;'>#迷迭香酸#</a>联合<a href='/topic/show?id=be7124e280e' target=_blank style='color:#2F92EE;'>#人参皂苷#</a>Rg1通过共同抑制<a href='/topic/show?id=34e6514391' target=_blank style='color:#2F92EE;'>#COX-2#</a>和<a href='/topic/show?id=d18a106e06bc' target=_blank style='color:#2F92EE;'>#PD1/PD-L1#</a>信号轴抑制<a href='/topic/show?id=3263e877271' target=_blank style='color:#2F92EE;'>#结肠癌#</a>转移，这个机制是比较有意思的。从中医角度，<a href='/topic/show?id=79b19463464' target=_blank style='color:#2F92EE;'>#迷迭香#</a>是<a href='/topic/show?id=7e98106e07fa' target=_blank style='color:#2F92EE;'>#芳香温通#</a>的作用，<a href='/topic/show?id=8a8624e210a' target=_blank style='color:#2F92EE;'>#人参#</a>扶正祛邪，二者配合，确实可能抑郁诸多<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>的作用，从信号角度而言，可能还会有其它更多的信号通路参与作用。当然温通的作用，从某种角度与抗炎镇痛相关，也即与COX-2相关，这种解释是合情合理的。而人参参与免疫调控，二者确实可能具有协同的作用。今后也许有一天这些小分子化合物能与当今最流行的<a href='/topic/show?id=a07f82814ec' target=_blank style='color:#2F92EE;'>#肿瘤免疫治疗#</a>形成配合，强化这一作用。就象<a href='/topic/show?id=2abb6606e9e' target=_blank style='color:#2F92EE;'>#淫羊藿苷#</a>一样，本身治疗肿瘤作用是弱的，但是可能与肿瘤免疫治疗形成协同作用。, objectTitle=Acta Pharmacol Sin：迷迭香酸联合人参皂苷Rg1通过共同抑制COX-2和PD1/PD-L1信号轴抑制结肠癌转移, objectType=article, longId=793952, objectId=260ae9395268, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20230927/1695825965883_5610093.jpg, objectUrl=/article/show_article.do?id=260ae9395268, replyNumber=0, likeNumber=154, createdTime=2023-09-28, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=260ae9395268, moduleTitle=Acta Pharmacol Sin：迷迭香酸联合人参皂苷Rg1通过共同抑制COX-2和PD1/PD-L1信号轴抑制结肠癌转移, moduleType=article, 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COX-2

2020-05-29

侠胆医心 (审核中...)

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全文收起 #迷迭香酸#联合#人参皂苷#Rg1通过共同抑制#COX-2#和#PD1/PD-L1#信号轴抑制#结肠癌#转移，这个机制是比较有意思的。从中医角度，#迷迭香#是#芳香温通#的作用，#人参#扶正祛邪，二者配合，确实可能抑郁诸多#肿瘤#的作用，从信号角度而言，可能还会有其它更多的信号通路参与作用。当然温通的作用，从某种角度与抗炎镇痛相关，也即与COX-2相关，这种解释是合情合理的。而人参参与免疫调控，二者确实可能具有协同的作用。今后也许有一天这些小分子化合物能与当今最流行的#肿瘤免疫治疗#形成配合，强化这一作用。就象#淫羊藿苷#一样，本身治疗肿瘤作用是弱的，但是可能与肿瘤免疫治疗形成协同作用。

Acta Pharmacol Sin：迷迭香酸联合人参皂苷Rg1通过共同抑制COX-2和PD1/PD-L1信号轴抑制结肠癌转移

2023-09-28发表于上海

手留余香 (审核中...)

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#COX-2#

Biomed Pharmacother：骨折患者如何预防cox-2特异性抑制剂的副作用

2019-08-10

手留余香 (审核中...)

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#COX-2#

J Steroid Biochem Mol Biol：IGF-1通过PI3K/AKT/COX-2途径逆转地塞米松对小鼠胚胎成纤维细胞中BMP9诱导的成骨

2019-04-28

手留余香 (审核中...)

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#COX-2#

Oncogene：在前列腺癌中，COX-2能够调控PKCε的促肿瘤作用

2018-05-30

手留余香 (审核中...)

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#COX-2#

Pharmacoepidemiol Drug Saf：选择性COX-2抑制剂或传统NSAIDs单独使用或联用PPIs患者的胃肠道毒性

2017-11-01

手留余香 (审核中...)

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#COX-2#

Cancer Immunol Res：COX-2抑制剂对抗癌治疗有帮助？

2017-07-23

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Cancer Res：COX-2抑制剂塞来昔布可能具有抗癌作用

2016-05-30

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Aliment Pharmacol Ther：选择性COX-2抑制剂+PPIs可显著降低NSAID相关胃肠道毒性风险

2016-05-21

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J Natl Cancer Inst：肺癌治疗的独特选择:解析COX-2抑制剂的应用

2015-01-07

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Circulation：连接COX-2抑制剂&心血管功能障碍的桥梁---ADMA（一氧化氮合成酶抑制剂）

2014-12-19

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Neurology：COX-2抑制剂与中风死亡率升高相关

2014-11-12

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EMA委员会：双氯芬酸的风险与COX-2抑制剂类似

2013-06-22

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Int J Oncol：川芎嗪靶向COX-2抑制肿瘤转移

2012-07-04

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Carcinogenesis：COX-2抑制剂对肿瘤EMT后更有效

2012-07-01

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COX-2抑制剂或能预防宫颈癌发病

2012-02-08

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通过ORAI1介导NF-κB信号通路激活组胺可调节肺癌细胞COX-2基因活性

2011-10-16

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Gut:选择性COX-2抑制剂塞来昔布单用对胃癌癌前病变有效

2011-10-16

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GUT:选择性COX-2抑制剂单用对胃癌癌前病变有效

2011-09-17

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