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Mutant U2AF1-induced differential alternative splicing causes an oxidative stress in bone marrow stromal cells

Liu, Z; Dong, XJ; Cao, ZJ; Qiu, SW; Li, YH; Zhong, MJ; Xue, ZY; Xu, YX; Xing, HY; Tang, KJ; Tian, Z; Wang, M; Rao, Q; Wang, JX

Rao, Q; Wang, JX (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, State Key Lab Expt Hematol, Tianjin 300020, Peoples R China.; Rao, Q; Wang, JX (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin 300020, Peoples R China.; Wang, JX (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, Tianjin 300020, Peoples R China.

EXPERIMENTAL BIOLOGY AND MEDICINE, 2021; 246 (15): 1750

Abstract

Alternative splicing (AS) is a critical regulatory process of gene expression. In bone marrow microenvironment, AS plays a critical role in mesenchyma......

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