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FOXM1 activates JAK1/STAT3 pathway in human osteoarthritis cartilage cell inflammatory reaction

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2021; 246 (6)

Osteoarthritis (OA), the most prevalent form of arthritis disease, is characterized by destruction of articular cartilage, osteophyte development, and......

Exploring effects of DNA methylation and gene expression on pan-cancer drug response by mathematical models

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2021; 246 (14)

Since genetic alteration only accounts for 20%-30% in the drug effect-related factors, the role of epigenetic regulation mechanisms in drug response i......

Inhibition of glioma by adenovirus KGHV500 encoding anti-p21Ras scFv and carried by cytokine-induced killer cells

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2021; 246 (10)

Ras gene mutation or overexpression can lead to tumorigenesis in multiple kinds of cancer, including glioma. However, no drugs targeting Ras or its ex......

Smad7 attenuates TGF-beta-mediated aging-related hypofunction of submandibular glands

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2021; 246 (11)

Submandibular glands have essential functions in taste, mastication, swallowing, and digestion. Submandibular gland hypofunction is prevalent in the e......

Arbutin ameliorates glucocorticoid-induced osteoporosis through activating autophagy in osteoblasts

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2021; 246 (14)

Chronic long-term glucocorticoid use causes osteoporosis partly by interrupting osteoblast homeostasis and exacerbating bone loss. Arbutin, a natural ......

Pathogenesis and brain functional imaging in nocturnal enuresis: A review

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2021; 246 (13)

Nocturnal enuresis is a common and distressing developmental disease, which may cause various degrees of psychosocial stress and impairment to self-es......

Identification of key biomarkers for thyroid cancer by integrative gene expression profiles

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2021; 246 (14)

Thyroid cancer is a frequently diagnosed malignancy and the incidence has been increased rapidly in recent years. Despite the favorable prognosis of m......

Importance of extracellular vesicles in hypertension

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2021; 246 (3)

Hypertension affects approximately 1.13 billion adults worldwide and is the leading global risk factor for cardiovascular, cerebrovascular, and kidney......

Immunomodulatory effects of mesenchymal stem cells for the treatment of cardiac allograft rejection

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2021; 246 (7)

Heart transplantation continues to be the gold standard clinical intervention to treat patients with end-stage heart failure. However, there are major......

Method used to establish a large animal model of drug-induced acute kidney injury

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2021; 246 (8)

Acute kidney injury is a serious health hazard disease due to its complex etiology and lack of effective treatments, resulting in high medical costs a......

Nuclear translocation of beta-catenin induced by E-cadherin endocytosis causes recurrent erosion of diabetic cornea

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2021; 246 (10)

Recurrent epithelial erosion and refractory corneal ulcer are the clinical features of diabetic keratopathy (DK), which eventually lead to corneal sca......

Mutant U2AF1-induced differential alternative splicing causes an oxidative stress in bone marrow stromal cells

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2021; 246 (15)

Alternative splicing (AS) is a critical regulatory process of gene expression. In bone marrow microenvironment, AS plays a critical role in mesenchyma......

Protective effects of molecular hydrogen on lung injury from lung transplantation

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2021; 246 (12)

Lung grafts may experience multiple injuries during lung transplantation, such as warm ischaemia, cold ischaemia, and reperfusion injury. These injuri......

Altered gene expression in glycolysis-cholesterol synthesis axis correlates with outcome of triple-negative breast cancer

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2021; 246 (5)

Identification of molecular subtypes of clinically resectable triple-negative breast cancer (TNBC) is of great importance to achieve better clinical o......

Nucleated red blood cells participate in myocardial regeneration in the toad Bufo Gargarizan Gargarizan

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2021; 246 (15)

Heart regeneration is negligible in humans and mammals but remarkable in some ectotherms. Humans and mammals lack nucleated red blood cells (NRBCs), w......

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