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Approach in Improving Potency and Selectivity of Kinase Inhibitors: Allosteric Kinase Inhibitors

Wei, SF; Zhao, TM; Wang, J; Zhai, X

Zhai, X (corresponding author), Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China.

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021; 21 (8): 991

Abstract

Allostery is an efficient and particular regulatory mechanism to regulate protein functions. Different from conserved orthosteric sites, allosteric si......

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