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SHP2 Inhibition Benefits Epidermal Growth Factor Receptor-mutated Non-Small Cell Lung Cancer Therapy

期刊: MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021; 21 (11)

EGFR-TKIs are confronted with big challenge of everlasting activated EGFR mutations which lack effective binding sites; this barrier is the dark side ......

The Efficacy of Natural Bioactive Compounds for the Treatment of Naso-pharyngeal Carcinoma

期刊: MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021; 21 (13)

The death toll associated with cancer worldwide is constantly on the increase. Efforts to combat and treat the different forms of this disease is also......

Approach in Improving Potency and Selectivity of Kinase Inhibitors: Allosteric Kinase Inhibitors

期刊: MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021; 21 (8)

Allostery is an efficient and particular regulatory mechanism to regulate protein functions. Different from conserved orthosteric sites, allosteric si......

Research Progress of Essential Oil as a New Complementary Therapy in the Treatment of Depression

期刊: MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021; 21 (16)

Depression is a mood disorder or affective disorder disease with depression as the main symptom. It has become a kind of mental disease that cannot be......

Multi-target Drug Design of Anti-Alzheimer's Disease based on Tacrine

期刊: MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021; 21 (15)

Alzheimer's disease (AD) is a progressive neurodegenerative disease with concealed onset, which is characterized by the damage of the cholinergic syst......

Recent Applications of Benzimidazole as a Privileged Scaffold in Drug Discovery

期刊: MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021; 21 (11)

Benzimidazole is an aromatic bicyclic heterocycle that is regarded as a valuable privileged scaffold in medicinal chemistry. Many marketed drugs and n......

Applications of ROS-InducedZr-MOFs Platform in Multimodal Synergis-tic Therapy

期刊: MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021; 21 (13)

Background: Metal-organic frameworks (MOFs) possess adjustable aperture, high load capacities, tailorable structures, and excellent biocompatibilities......

Reviewing Propolis with Multi-components in the Treatment of Oral Diseases through Multi-pathways and Multi-targets

期刊: MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021; 21 (12)

Propolis is a natural product made from the mixture of plant resin, saliva and wax collected by bees. It has been studied and concerned because of its......

Recent Progress in the Drug Development for the Treatment of Alzheimer's Disease Especially on Inhibition of Amyloid-peptide Aggregation

期刊: MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021; 21 (8)

As the world's population is aging, Alzheimer's disease (AD) has become a big concern since AD has started affecting younger people and the population......

Recent Applications of Azo Dyes: A Paradigm Shift from Medicinal Chemistry to Biomedical Sciences

期刊: MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021; 21 (9)

Azo molecules possess the characteristic azo bond (-N=N-) and are considered fascinating motifs in organic chemistry. Since the last century, these br......

Advances on the Anti-Inflammatory Activity of Oleanolic Acid and Derivatives

期刊: MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021; 21 (15)

Oleanolic acid can inhibit edema and exhibit obvious inhibitory activity to inflammatory by activating of the pituitary-adrenal cortical system, inhib......

Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships

期刊: MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021; 21 (14)

Cholesterol, steroid alcohol, was discovered by M.E. Chevreul in 1815. Cholesterol and its derivatives showed a large variety of biological properties......

A Brief Introduction to Porphyrin Compounds used in Tumor Imaging and Therapies

期刊: MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021; 21 (11)

As a group of heterocyclic macrocycle organic natural compounds occurring universally in animal tissues and plants, porphyrins are composed of four mo......

SET Protein in Cancer: A Potential Therapeutic Target

期刊: MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021; 21 (16)

SET protein is a multi-functional oncoprotein that is ubiquitously expressed in most tumor cells. Dysregulation of SET has been associated with many t......

Origins, Structures, and Bioactivities of Secondary Metabolites from Marine-derived Penicillium Fungi

期刊: MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021; 21 (15)

In recent years, marine-derived Penicillium fungi have received remarkable interest as a valuable source of novel natural products encompassing divers......

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