Baidu
map

Stroke:卒中家族史与卒中复发相关,尤其是早发性卒中

2016-07-17 phylis 译 MedSci原创

背景:卒中家族史与卒中复发的关系仍不清楚。方法:应用基于Web的多中心脑卒中登记数据库,收集发病7天内住院的卒中患者,一级亲属卒中史的数据。对采集的信息进行如下分类:受影响的亲属(S)(父亲、母亲、兄弟姐妹,或两者都有或更多),脑卒中发病年龄(<50,50-59岁、60-69岁,和≥70年)。使用预定的协议,前瞻性地调查脑卒中的复发。根据患者的年龄对卒中指数进行亚组分析。结果:7642例患者中,9

背景:卒中家族史与卒中复发的关系仍不清楚。

方法:应用基于Web的多中心脑卒中登记数据库,收集发病7天内住院的卒中患者,一级亲属卒中史的数据。对采集的信息进行如下分类:受影响的亲属(S)(父亲、母亲、兄弟姐妹,或两者都有或更多),脑卒中发病年龄(<50,50-59岁、60-69岁,和≥70年)。使用预定的协议,前瞻性地调查脑卒中的复发。根据患者的年龄对卒中指数进行亚组分析。

结果:7642例患者中,937(12.3%)例患者一级亲属有卒中史,475例患者(6.2%:201例在卒中指数内,274后卒中后3周)卒中复发(随访中位数,365天)。多变量Cox比例风险模型,整个家族史与脑卒中复发不相关(风险比,1.08;95%置信区间,0.81-1.43)。然而,校正潜在的混杂因素后,脑卒中发病的相对年龄(<50岁:HR,2.14;95%CI,1.004-4.54)和兄弟姐妹卒中史(HR,1.67;95%CI,1.09-2.58)与卒中复发独立相关。年轻的卒中患者(年龄小于55岁)比老年的卒中患者相关性更强。

结论:这项研究表明,兄弟姐妹存在早发卒中,卒中复发风险升高,这意味着需要对这类人群进行额外的预防措施。

原始出处:

Chung JW, Kim BJ, et al. Family History and Risk of Recurrent Stroke. Stroke. 2016 Jul 12.


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1664022, encodeId=34561664022bc, content=<a href='/topic/show?id=a20c59283e5' target=_blank style='color:#2F92EE;'>#早发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59283, encryptionId=a20c59283e5, topicName=早发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06c425715601, createdName=ms7258648636991762, createdTime=Tue Dec 27 12:43:00 CST 2016, time=2016-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145510, encodeId=d9fd145510c1, content=好文值得点赞!继续关注学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:26:51 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391602, encodeId=2ff81391602da, content=<a href='/topic/show?id=f8ab3603664' target=_blank style='color:#2F92EE;'>#卒中复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36036, encryptionId=f8ab3603664, topicName=卒中复发)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLc3PoqaNe4QTZ947pojXuchvvmkkJN0wyBBbA3LVX2WDkgiaJ7cswu9yvA4CB0NicjcrCfBY1zRPkA/132, createdBy=b3812500089, createdName=ms6897892027066920, createdTime=Tue Jul 19 10:43:00 CST 2016, time=2016-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479786, encodeId=90ef14e9786c6, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Tue Jul 19 10:43:00 CST 2016, time=2016-07-19, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1664022, encodeId=34561664022bc, content=<a href='/topic/show?id=a20c59283e5' target=_blank style='color:#2F92EE;'>#早发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59283, encryptionId=a20c59283e5, topicName=早发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06c425715601, createdName=ms7258648636991762, createdTime=Tue Dec 27 12:43:00 CST 2016, time=2016-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145510, encodeId=d9fd145510c1, content=好文值得点赞!继续关注学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:26:51 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391602, encodeId=2ff81391602da, content=<a href='/topic/show?id=f8ab3603664' target=_blank style='color:#2F92EE;'>#卒中复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36036, encryptionId=f8ab3603664, topicName=卒中复发)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLc3PoqaNe4QTZ947pojXuchvvmkkJN0wyBBbA3LVX2WDkgiaJ7cswu9yvA4CB0NicjcrCfBY1zRPkA/132, createdBy=b3812500089, createdName=ms6897892027066920, createdTime=Tue Jul 19 10:43:00 CST 2016, time=2016-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479786, encodeId=90ef14e9786c6, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Tue Jul 19 10:43:00 CST 2016, time=2016-07-19, status=1, ipAttribution=)]
    2016-10-11 ylzr123

    好文值得点赞!继续关注学习。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1664022, encodeId=34561664022bc, content=<a href='/topic/show?id=a20c59283e5' target=_blank style='color:#2F92EE;'>#早发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59283, encryptionId=a20c59283e5, topicName=早发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06c425715601, createdName=ms7258648636991762, createdTime=Tue Dec 27 12:43:00 CST 2016, time=2016-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145510, encodeId=d9fd145510c1, content=好文值得点赞!继续关注学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:26:51 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391602, encodeId=2ff81391602da, content=<a href='/topic/show?id=f8ab3603664' target=_blank style='color:#2F92EE;'>#卒中复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36036, encryptionId=f8ab3603664, topicName=卒中复发)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLc3PoqaNe4QTZ947pojXuchvvmkkJN0wyBBbA3LVX2WDkgiaJ7cswu9yvA4CB0NicjcrCfBY1zRPkA/132, createdBy=b3812500089, createdName=ms6897892027066920, createdTime=Tue Jul 19 10:43:00 CST 2016, time=2016-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479786, encodeId=90ef14e9786c6, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Tue Jul 19 10:43:00 CST 2016, time=2016-07-19, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1664022, encodeId=34561664022bc, content=<a href='/topic/show?id=a20c59283e5' target=_blank style='color:#2F92EE;'>#早发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59283, encryptionId=a20c59283e5, topicName=早发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06c425715601, createdName=ms7258648636991762, createdTime=Tue Dec 27 12:43:00 CST 2016, time=2016-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145510, encodeId=d9fd145510c1, content=好文值得点赞!继续关注学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:26:51 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391602, encodeId=2ff81391602da, content=<a href='/topic/show?id=f8ab3603664' target=_blank style='color:#2F92EE;'>#卒中复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36036, encryptionId=f8ab3603664, topicName=卒中复发)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLc3PoqaNe4QTZ947pojXuchvvmkkJN0wyBBbA3LVX2WDkgiaJ7cswu9yvA4CB0NicjcrCfBY1zRPkA/132, createdBy=b3812500089, createdName=ms6897892027066920, createdTime=Tue Jul 19 10:43:00 CST 2016, time=2016-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479786, encodeId=90ef14e9786c6, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Tue Jul 19 10:43:00 CST 2016, time=2016-07-19, status=1, ipAttribution=)]

相关资讯

Stroke:血红蛋白浓缩与卒中发生风险

在之前的观察性研究中发现,血红蛋白浓缩和卒中风险增加相关。然而,这些研究受限于相对不足的卒中事件数量,因此难以判断血红蛋白浓缩和卒中风险增加之间的联系是由于人口统计的差异还是临床影响因素。研究方法:我们的研究对象来自卒中地域及人种差异原因研究(REGARDS研究),这项研究由一个年龄不小于45岁的黑种人和白种人的队列构成,然后使用Cox比例风险分析和Kaplan–Meier生存分析对血红蛋白浓缩的

Stroke:卒中前危险因素可严重影响复发性卒中和卒中后痴呆症

改善卒中后短期生存,有必要量化卒中后(即复发性卒中和痴呆)的长期后遗症的风险和危险因素。这种风险可能会受到初发卒中暴露于心血管危险因素的影响。在基于人群的Rotterdam研究中,研究人员确定了卒中复发和老年痴呆症的长期风险,以及由于卒中前的心血管危险因素(即人群归因危险度)引起的复发性卒中和卒中后痴呆症比例。研究人员随访了1237例首次卒中患者和4928名无卒中的参与者,为卒中或痴呆发生匹配了年

Ann Emerg Med:大多数高血压相关的急诊就诊是不必要的

近期发表在Annals of Emergency Medicine的研究数据显示,增加对血压的家庭监测,可能会导致不必要的急诊(ED)就诊。新宁保健科学中心急救医生Clare Atzema博士和同事对加拿大安大略2002-2012年主要诊断为高血压的206147名(平均年龄为64岁)患者的ED数据进行了研究分析。大多数患者(81.4%)有高血压病史,一些患者有糖尿病(20.9%)、慢性阻塞性肺疾病

Stroke:卒中或TIA后,应长期进行动态心电图监测

背景:心房颤动的监测和治疗是脑卒中二级预防的主要目标。指南推荐卒中后心电图监测至少24小时。然而,在临床实践中目前还不清楚心电监护的使用频率。方法: 这项纵向队列研究使用来自安大略卒中登记记录中的数据,研究者分析加拿大,安大略卒中中心(2003-2013)的窦性心律和无房颤,并且首发急性缺血性卒中或短暂性脑缺血发作(TIA)。主要预后是卒中/TIA后30天内进行24小时动态心电图监测的患者比例。二

Srtoke:既往发生脑卒中的患者中,依度沙班VS华法林

房颤及曾有卒中(IS)或短暂性脑缺血发作(TIA)病史的患者在抗凝下仍有较高再发脑血管事件风险。在这个预先设定的亚组分析中,我们对比了使用华法林和依度沙班在有或没有既往 IS/TIA病史患者中情况。 研究方法:ENGAGE AF-TIMI 48(心源性梗死房颤栓塞病人中下代Xa因子抑制剂有效抗凝48号研究)是由21105位随机分配到华法林组(国际标准化比值,2.0–3.0:中位达标

女性房颤患者的卒中住院风险更高

近期Cardiostim-EHRA Europace 2016上称,房颤(AF)患者15年的研究表明,女性因急性缺血性脑卒中住院可能性比男性高23%。爱荷华大学医院的Ghanshyam Palamaner Shantha对1998到2012年的110万例AF患者数据进行了分析研究,探究房颤和急性缺血性脑卒中住院率之间是否存在关系。数据显示,AF患者在15年期间的急性缺血性中风住院率为:女性为2.1

Baidu
map
Baidu
map
Baidu
map