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Medicine:HCV感染者脑出血风险增加,尤其是年轻患者

2015-11-21 phylis 译 MedSci原创

本研究探讨丙型肝炎病毒(HCV)感染是否可导致脑出血。在台湾国家健康保险数据中,2000年和2010年诊断为丙型肝炎病毒感染的患者9023名,按照年龄,性别配对随机选出无HCV感染的受试者36092名。在2011年底评估HCV感染患者ICH发生的风险,及受试者糖尿病,高血压合,缺血性心脏病,高脂血症,心房纤颤,酒精性肝疾病,颅脑损伤等共存病。应用多变量COX回归分析评估,HCV感染的患者比对照组受

本研究探讨丙型肝炎病毒(HCV)感染是否可导致脑出血。

在台湾国家健康保险数据中,2000年和2010年诊断为丙型肝炎病毒感染的患者有9023名,按照年龄、性别配对随机选出无HCV感染的受试者36092名。在2011年底评估HCV感染患者ICH发生的风险,及受试者糖尿病、高血压、缺血性心脏病、高脂血症、房颤、酒精性肝疾病、颅脑损伤等共存病。

应用多变量COX回归分析评估,HCV感染的患者比对照组受试者发生ICH的风险增高,校正HR值:1.60(95% CI:1.24-2.06)。年龄特异性分析表明年龄较轻的HCV患者发生ICH的风险增加,年龄≤55和56-64岁发生ICH风险的校正HR值分别为1.92(95%CI:1.18-3.11)和2.45(95%CI:1.52-3.98)。严重HCV感染的患者,ICH发生的风险增加,轻度和重度HCV感染发生ICH的校正HR值分别为1.66(95%CI:1.21-2.30 AHR)和2.12(95%CI:1.47-3.06)。没有共存病的患者,ICH发生的风险为2.33(95%CI:1.36-3.98),HCV组高于对照组。

研究者发现,HCV感染的患者于ICH发生的风险增加相关,尤其是在相对年轻的患者。

原文出处:

Tseng CH, Muo CH, Hsu CY, Kao CH. Increased Risk of Intracerebral Hemorrhage Among Patients With Hepatitis C Virus Infection.  Medicine (Baltimore). 2015 Nov.


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    2016-10-08 1e137bdcm70(暂无匿称)

    这个研究的思路可以借鉴,以后在临床研究中应该多思考,寻找科研亮点

    0

  2. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Sat Sep 10 15:13:00 CST 2016, time=2016-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858636, encodeId=02821858636fc, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Sun Dec 27 15:52:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54725, encodeId=b84454e2555, content=好东西,值得分享,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, 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    2016-09-23 kalseyzl
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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 02:04:00 CST 2015, time=2015-12-28, status=1, ipAttribution=)]
    2016-09-10 医路开来

    年轻人风险大

    0

  4. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=119336, encodeId=c65b11933694, content=年轻人风险大, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Sat Sep 10 15:14:00 CST 2016, time=2016-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=119339, encodeId=b9a811933950, content=学习啦,要掌握, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 02:04:00 CST 2015, time=2015-12-28, status=1, ipAttribution=)]
    2016-09-10 医路开来

    学习啦,要掌握

    0

  5. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 02:04:00 CST 2015, time=2015-12-28, status=1, ipAttribution=)]
    2016-09-10 医路开来

    丙型肝炎病毒(HCV)感染是否可导致脑出血。

    0

  6. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 02:04:00 CST 2015, time=2015-12-28, status=1, ipAttribution=)]
    2016-09-10 医路开来

    积极治疗原发病

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Sat Sep 10 15:13:00 CST 2016, time=2016-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858636, encodeId=02821858636fc, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Sun Dec 27 15:52:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54725, encodeId=b84454e2555, content=好东西,值得分享,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69b61619007, createdName=andruhn, createdTime=Fri Jan 08 20:09:00 CST 2016, time=2016-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49787, encodeId=307649e8766, content=不错哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 02:05:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49785, encodeId=626549e855e, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 02:04:00 CST 2015, time=2015-12-28, status=1, ipAttribution=)]
    2015-12-27 jeanqiuqiu
  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69b61619007, createdName=andruhn, createdTime=Fri Jan 08 20:09:00 CST 2016, time=2016-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49787, encodeId=307649e8766, content=不错哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 02:05:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49785, encodeId=626549e855e, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 02:04:00 CST 2015, time=2015-12-28, status=1, ipAttribution=)]
    2016-01-08 andruhn

    好东西,值得分享,学习了!

    0

  9. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 02:04:00 CST 2015, time=2015-12-28, status=1, ipAttribution=)]
    2015-12-28 wzf990214

    不错哦

    0

  10. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 02:04:00 CST 2015, time=2015-12-28, status=1, ipAttribution=)]
    2015-12-28 wzf990214

    有意思

    0

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