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JAMA Pediatr:青少年服用阿片类药物导致精神心理疾病风险增加

2018-03-13 zhangfan MedSci原创

研究认为,青少年阿片类长期服用率较低,但阿片类暴露与青少年精神心理障碍之间的相关性却十分显著

成年人群中,长期接受阿片类药物治疗导致精神疾病风险增加,但阿片类暴露对青少年精神心理疾病风险的影响尚不清楚。近日研究人员考察了青少年心理健康状况与长期阿片治疗之间的关系。

1224520名14-18岁的,非癌阿片类服用者参与研究,比较阿片类服用人群与未服用人群心理健康状况和治疗之间的差异,定义90天以上的阿片类治疗为长期阿片暴露。

参与者首次接受阿片处方年龄为17岁,女生占51.1%,平均随访625天。接受阿片治疗的青少年,其焦虑、情绪障碍、神经发育障碍、睡眠障碍、非阿片类物质使用障碍的风险增加(风险比值比由非阿片类物质使用障碍风险的1.13到非苯二氮卓类催眠药滥用风险的1.69)。81.7%的患者接受至少6个月的随访,每1000患者中3人长期阿片暴露,长期暴露导致患者精神心理疾病及治疗风险增加(风险比值比由注意缺陷/多动障碍风险的1.73到阿片类使用障碍风险的8.90)。

研究认为,青少年阿片类长期服用率较低,但阿片类暴露与青少年精神心理障碍之间的相关性却十分显著。

原始出处:


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    2018-12-11 feather89
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    2018-03-15 lhlxtx
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1727150, encodeId=9ca61e27150b9, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Dec 11 10:39:00 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910441, encodeId=be251910441f1, content=<a href='/topic/show?id=27bce6523e6' target=_blank style='color:#2F92EE;'>#精神心理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76523, encryptionId=27bce6523e6, topicName=精神心理)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Fri Mar 23 07:39:00 CST 2018, time=2018-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638485, encodeId=3cdf163848567, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Aug 19 18:39:00 CST 2018, time=2018-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253057, encodeId=a405125305ea8, content=<a href='/topic/show?id=13159e8871d' target=_blank style='color:#2F92EE;'>#阿片类药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97887, encryptionId=13159e8871d, topicName=阿片类药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c83329, createdName=10518093zz, createdTime=Thu Mar 15 05:39:00 CST 2018, time=2018-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309089, encodeId=deb1130908990, content=<a href='/topic/show?id=a0179e879ac' target=_blank style='color:#2F92EE;'>#阿片类#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97879, encryptionId=a0179e879ac, topicName=阿片类)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e12358, createdName=lhlxtx, createdTime=Thu Mar 15 05:39:00 CST 2018, time=2018-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473105, encodeId=daf114e310549, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Thu Mar 15 05:39:00 CST 2018, time=2018-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295863, encodeId=c97429586397, content=好好努力.继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Mar 13 15:20:57 CST 2018, time=2018-03-13, status=1, ipAttribution=)]
    2018-03-13 忠诚向上

    好好努力.继续学习

    0

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