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Hypertension:高血压是否导致认知功能障碍?

2017-10-19 MedSci MedSci原创

有研究表明,高血压可能是认知过早衰退的风险因素之一。然而,降低血压(BP)并不能一致地逆转认知衰退,这表明高血压本身可能不会导致认知衰退。近期,一项发表在杂志Hypertension上的研究假设了原发性高血压对大脑有初步影响,随着时间的推移,表现为认知功能障碍与脑血管异常和系统性血压升高的相结合。基于此,研究者们测试了高血压前期个体对认知挑战的神经心理功能和脑血流量反应是否会预测随后BP的进展。具

有研究表明,高血压可能是认知过早衰退的风险因素之一。然而,降低血压(BP)并不能一致地逆转认知衰退,这表明高血压本身可能不会导致认知衰退。近期,一项发表在杂志Hypertension上的研究假设了原发性高血压对大脑有初步影响,随着时间的推移,表现为认知功能障碍与脑血管异常和系统性血压升高的相结合。基于此,研究者们测试了高血压前期个体对认知挑战的神经心理功能和脑血流量反应是否会预测随后BP的进展。具有高血压前期BP的中年成人(n = 154;平均年龄49岁;45%男性)进行神经心理测试并评估区域脑血流量(rCBF)对认知挑战的反应。由语言和逻辑记忆(记忆),执行功能,工作记忆,精神效能和注意力评估神经心理表现。伪连续动脉自旋标记磁共振成像序列将rCBF反应与认知挑战的控制和活动期进行比较。以前与BP相关的脑区域划分为前额叶,前额叶和岛皮质下rCBF区域。使用多元回归模型测试能否通过初始BP,初始神经心理学评分和对认知挑战的初始rCBF反应预测2年后的BP。结果显示:工作记忆(标准化β,-0.276; se = 0.116; P = 0.02)和对认知挑战(标准化β,0.234; se =

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    2018-05-28 feather89
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    2017-10-20 flysky120

    学习一下知识谢谢

    0

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    2017-10-20 欧阳星月dora

    已学习.谢谢分享

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2038772, encodeId=96212038e72d1, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Mon Oct 01 13:52:00 CST 2018, time=2018-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726813, encodeId=805f1e2681340, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon May 28 07:52:00 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421104, encodeId=61261421104b6, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Sat Oct 21 11:52:00 CST 2017, time=2017-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501219, encodeId=338d1501219e5, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sat Oct 21 11:52:00 CST 2017, time=2017-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254539, encodeId=a455254539a6, content=学习一下知识谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Fri Oct 20 09:05:00 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254533, encodeId=c6e2254533d5, content=已学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/be4YlKNv3rT6se8HUMWmAyS3eywXjKkf3TaeJkKrgAdTM1l1WesYwgkw2VAOVEWicdb6rCiaRbttqjb9ozpjCkGQ/0, createdBy=2d322139779, createdName=欧阳星月dora, createdTime=Fri Oct 20 08:58:22 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254396, encodeId=0f6c25439665, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Oct 19 22:18:33 CST 2017, time=2017-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254372, encodeId=79282543e23d, content=有研究表明.高血压可能是认知过早衰退的风险因素之一.然而.降低血压(BP)并不能一致地逆转认知衰退.这表明高血压本身可能不会导致认知衰退, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Thu Oct 19 21:18:04 CST 2017, time=2017-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254368, encodeId=0cb2254368af, content=猜也能猜到..., beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/10/16d33b9abecd6440b30b37e6ad8db1a6.jpg, createdBy=f6f72168266, createdName=阿杜12138, createdTime=Thu Oct 19 21:12:20 CST 2017, time=2017-10-19, status=1, ipAttribution=)]
    2017-10-19 惠映实验室

    学习了.谢谢.

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2038772, encodeId=96212038e72d1, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Mon Oct 01 13:52:00 CST 2018, time=2018-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726813, encodeId=805f1e2681340, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon May 28 07:52:00 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421104, encodeId=61261421104b6, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Sat Oct 21 11:52:00 CST 2017, time=2017-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501219, encodeId=338d1501219e5, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sat Oct 21 11:52:00 CST 2017, time=2017-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254539, encodeId=a455254539a6, content=学习一下知识谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Fri Oct 20 09:05:00 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254533, encodeId=c6e2254533d5, content=已学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/be4YlKNv3rT6se8HUMWmAyS3eywXjKkf3TaeJkKrgAdTM1l1WesYwgkw2VAOVEWicdb6rCiaRbttqjb9ozpjCkGQ/0, createdBy=2d322139779, createdName=欧阳星月dora, createdTime=Fri Oct 20 08:58:22 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254396, encodeId=0f6c25439665, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Oct 19 22:18:33 CST 2017, time=2017-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254372, encodeId=79282543e23d, content=有研究表明.高血压可能是认知过早衰退的风险因素之一.然而.降低血压(BP)并不能一致地逆转认知衰退.这表明高血压本身可能不会导致认知衰退, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Thu Oct 19 21:18:04 CST 2017, time=2017-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254368, encodeId=0cb2254368af, content=猜也能猜到..., beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/10/16d33b9abecd6440b30b37e6ad8db1a6.jpg, createdBy=f6f72168266, createdName=阿杜12138, createdTime=Thu Oct 19 21:12:20 CST 2017, time=2017-10-19, status=1, ipAttribution=)]
    2017-10-19 有备才能无患

    有研究表明.高血压可能是认知过早衰退的风险因素之一.然而.降低血压(BP)并不能一致地逆转认知衰退.这表明高血压本身可能不会导致认知衰退

    0

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    2017-10-19 阿杜12138

    猜也能猜到...

    0

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