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Hypertension:如何控制2型糖尿病高血压患者的收缩压?

2017-10-19 MedSci MedSci原创

目前,有主张对糖尿病患者收缩压(SBP)的管理从统一性改为以个体化、以患者为中心,但对于实现治疗目标的SBP水平尚未达成共识。近期,一项发表在杂志Hypertension上的研究旨在评估SBP与心血管疾病(CVD)风险和糖尿病患者的全因死亡率之间的关系,以确定以患者为中心的治疗目标。此项研究对95086名2型糖尿病和高血压成人初级保健患者进行了回顾性研究。使用年度SBP记录(更新的SBP),平均随

目前,有主张对糖尿病患者收缩压(SBP)的管理从统一性改为以个体化、以患者为中心,但对于实现治疗目标的SBP水平尚未达成共识


近期,一项发表在杂志Hypertension上的研究旨在评估SBP与心血管疾病(CVD)风险和糖尿病患者的全因死亡率之间的关系,以确定以患者为中心的治疗目标。

此项研究对95086名2型糖尿病高血压成人初级保健患者进行了回顾性研究。使用年度SBP记录(更新的SBP),平均随访时间为5.9年,使用Cox比例风险回归评估总体CVD、全因死亡率及其与SBP相关的复合体的风险。通过分层患者的基线特征对CVD的发生率进行亚组分析。
 
此项研究结果显示:2型糖尿病患者的CVD和全因死亡风险最低的SBP范围为130〜134 mmHg。在不考虑患者的特征的情况下,SBP与CVD和全因死亡风险之间为J型曲线关系。

此外,所有患有SBP <125 mm Hg或≥140mm Hg的患者,其CVD和死亡风险均升高。无论患者的特征如何,药物治疗中SBP达到125至139 mmHg的水平,这表明在糖尿病管理中,SBP治疗目标<140 mmHg和个体化的SBP靶标可能不是必需的。

原始出处:
Wan EYF, Yu EYT, et al. Do We Need a Patient-Centered Target for Systolic Blood Pressure in Hypertensive Patients With Type 2 Diabetes Mellitus? Hypertension. 2017 Oct 16. pii: HYPERTENSIONAHA.117.10034. doi: 10.1161/HYPERTENSIONAHA.117.10034.

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    2018-04-03 feather89
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    2017-10-20 1391e9f2a7m

    好文章.认真学习了

    0

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    2017-10-19 changjiu

    学习了.谢谢

    0

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