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三阴性乳腺癌:令人闻风丧胆的肿瘤!3种新疗法或将提高生存率

2020-09-11 三阴性乳腺癌 三阴性乳腺癌

乳腺癌是女性恶性肿瘤之首,但随着医学技术的发展,大部分的乳腺癌生存率渐渐拔高,但仍然有一种让肿瘤医生格外头疼,它就是三阴性乳腺癌。 “我的木子走了”唐家三少妻子妻子患癌去世 2015年,当唐家三少准备

乳腺癌是女性恶性肿瘤之首,但随着医学技术的发展,大部分的乳腺癌生存率渐渐拔高,但仍然有一种让肿瘤医生格外头疼,它就是三阴性乳腺癌。

“我的木子走了”唐家三少妻子患癌去世

2015年,当唐家三少准备动手给妻子写一本小说的时候,妻子恰好在那个时候被查出了乳腺癌。

2016年,手术后的第二次复查,情况不容乐观,淋巴多发性转移、胸骨转移以及肝转移。而且医生明确表示,这是三阴乳腺癌,没有靶向药,只能进行化疗。而且肝转移的情况,生存年限可能只剩下一年半了。

但是,他不准备放弃。

使用紫杉醇化疗九个月,前期有效果,但是之后出现耐药现象,并且伴随扩散。之后换用药物艾日布林,只维持了两个月。再之后,尝试免疫疗法,最初效果不错,但只维持了小半年。

直到2018年9月,唐家三少的妻子去世。

之后,他连续发了两条微博寄哀思。文字虽然不多,但我们都能看出三少的不舍。

三阴性乳腺癌,到底有多可怕?

乳腺癌是威胁女性健康的主要杀手,分类上,乳腺癌主要有三个主要的类型,激素受体阳性、HER2阳性和阴性、三阴性。三阴性乳腺癌发病率占到乳腺癌总发病率的10%到20.8%,而且它的发病年龄比较小,好发于40岁以下、绝经之前的年轻女性。更要命的是,三阴性乳腺癌侵袭性强,极易发生远处转移已经局部位置的复发。

其他类型的乳腺癌患者,五年生存率可以达到90%,而三阴性乳腺癌,早期治疗后的五年生存率为77%,如果确诊晚了的话,五年生存率会下降到14%。所以,它的恶性程度相对于其他类型的乳腺癌,相当的高。

目前,明确有效的治疗手段就是化疗。但是由于存在其他部位的转移,这就导致治疗的难度加大,而药物的选择方面又进一步变得逼仄了。难治、复发性强、大面积转移,这在治疗上基本无解。

三阴性乳腺癌困局如何破?科学家找到了新方法

●免疫联合化疗

虽然治疗难度大,但是世界各国的医疗卫生领域,也一直在寻找攻克其的新办法。这不,免疫联合化疗的办法,在临床试验上有了一定的新进展。

在今年的6月18日,医药研发生产商罗氏宣布,在三期临床的试验中,早期的三阴性乳腺癌患者,采取阿替利珠单抗的免疫疗法,联合化疗的治疗方式,达到了病理完全缓解的预期。与对照组相比,采取了阿替利珠单抗联合化疗的治疗后,早期患者在接受手术时,肿瘤组织变小甚至消失的情况更多。这样的结果,意味着在三阴性乳腺癌的治疗上,有了一定的新突破。

●节拍化疗

除了有新领域和新突破,在传统的化疗方式上,“节拍化疗”法也在常规的治疗上有了一定的新突破。

所谓“节拍化疗”,就是降低药物的剂量,只有常规用药量的三分之一甚至十分之一,同时提高用药的频率,每周持续用药1到3次,这样一来,降低了药物的毒副反应,同样又可以延长用药的总时长,进而可以达到控制癌细胞的目的。目前,临床应用上,该疗法使复发风险降低了37%。

●靶向药

今年的4月22日,美国食药监局批准了第一款用于治疗三阴性乳腺癌的靶向药Trodelvy,这项靶向药主要针对的是使用过两种化疗方案的转移性三阴性乳腺癌患者。目前,该药在我国的临床试验已经获批,第一期的临床试验即将展开。

虽然病情凶险,但专家们还是在努力发掘抑制它的方法。所以对于乳腺癌患者而言,积极的配合治疗,不主动放弃,才会出现各种新的可能。癌症虽然可怕,但是治疗的过程,也是患者自己向疾病发出的强有力的呐喊,这会激励更多专业人员,去研究新的治疗方法。

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objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=626e1296645, createdName=573722703, createdTime=Fri Sep 11 16:35:55 CST 2020, time=2020-09-11, status=1, ipAttribution=)]
    2020-10-28 ms3000002005028696

    抗癌药物的研发仍然是任重道远

    0

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    2020-09-13 xlysu
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    2020-09-13 kcb074
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topicName=新疗法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d03114536414, createdName=kcb074, createdTime=Sun Sep 13 06:44:17 CST 2020, time=2020-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884572, encodeId=a56d8845e200, content=<a href='/topic/show?id=5fe1103e7293' target=_blank style='color:#2F92EE;'>#节拍化疗#</a>是用于<a href='/topic/show?id=33771982175' target=_blank style='color:#2F92EE;'>#三阴性乳腺癌#</a>当前的一个较好的手段。在卵巢癌,胰腺癌中也在尝试中, beContent=null, objectType=article, channel=null, level=null, likeNumber=235, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=103772, encryptionId=5fe1103e7293, topicName=节拍化疗), TopicDto(id=19821, encryptionId=33771982175, topicName=三阴性乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 11 16:37:54 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884618, encodeId=03f58846180f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec925417492, createdName=ms8000000896283797, createdTime=Fri Sep 11 20:37:47 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884617, encodeId=1d2688461e45, content=说得好, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec925417492, createdName=ms8000000896283797, createdTime=Fri Sep 11 20:37:40 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884568, encodeId=128a884568c9, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=626e1296645, createdName=573722703, createdTime=Fri Sep 11 16:35:55 CST 2020, time=2020-09-11, status=1, ipAttribution=)]
    2020-09-11 lovetcm

    #节拍化疗#是用于#三阴性乳腺癌#当前的一个较好的手段。在卵巢癌,胰腺癌中也在尝试中

    1

    展开1条回复
  8. 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topicName=新疗法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d03114536414, createdName=kcb074, createdTime=Sun Sep 13 06:44:17 CST 2020, time=2020-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884572, encodeId=a56d8845e200, content=<a href='/topic/show?id=5fe1103e7293' target=_blank style='color:#2F92EE;'>#节拍化疗#</a>是用于<a href='/topic/show?id=33771982175' target=_blank style='color:#2F92EE;'>#三阴性乳腺癌#</a>当前的一个较好的手段。在卵巢癌,胰腺癌中也在尝试中, beContent=null, objectType=article, channel=null, level=null, likeNumber=235, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=103772, encryptionId=5fe1103e7293, topicName=节拍化疗), TopicDto(id=19821, encryptionId=33771982175, topicName=三阴性乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 11 16:37:54 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884618, encodeId=03f58846180f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec925417492, createdName=ms8000000896283797, createdTime=Fri Sep 11 20:37:47 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884617, encodeId=1d2688461e45, content=说得好, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec925417492, createdName=ms8000000896283797, createdTime=Fri Sep 11 20:37:40 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884568, encodeId=128a884568c9, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=626e1296645, createdName=573722703, createdTime=Fri Sep 11 16:35:55 CST 2020, time=2020-09-11, status=1, ipAttribution=)]
    2020-09-11 ms8000000896283797

    学习了

    0

  9. 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time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884618, encodeId=03f58846180f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec925417492, createdName=ms8000000896283797, createdTime=Fri Sep 11 20:37:47 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884617, encodeId=1d2688461e45, content=说得好, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec925417492, createdName=ms8000000896283797, createdTime=Fri Sep 11 20:37:40 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884568, encodeId=128a884568c9, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=626e1296645, createdName=573722703, createdTime=Fri Sep 11 16:35:55 CST 2020, time=2020-09-11, status=1, ipAttribution=)]
    2020-09-11 ms8000000896283797

    说得好

    0

  10. 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