Pain:脑干三叉神经纤维微结构异常与三叉神经痛各亚型的治疗反应有关

2021-06-28 MedSci原创 MedSci原创

这些新的发现证明了DTI作为一种客观、无创的治疗反应预测工具的价值，并阐明了TN人群中治疗反应者和无反应者的区别。

三叉神经痛(TN)的神经外科治疗可以持久缓解疼痛；然而，一些患者没有反应，需要进行多次重复的手术。手术结果可能因TN的类型而异，但原因尚不清楚。TN的神经影像学研究提示三叉神经脑干纤维异常；然而，这是否是不同亚型TN治疗无反应的共同特征尚不清楚。 Mojgan Hodaie等在使用弥散张量成像(DTI)来确定脑干三叉神经纤维微结构是否是TN手术反应的常见生物标志物，以及这些异常的程度是否与跨亚型TN反应的可能性相关。研究成果发表在Pain杂志。研究了98例接受神经外科治疗的TN患者（61例经典型TN，26例继发于多发性硬化，11例伴有孤立性桥脑病变）和50例健康对照。通过疼痛强度测量来评估治疗反应，并通过提取三叉神经近侧桥段的治疗前DTI指标来检查显微结构特征。三叉神经多传感器扩散束成像及ROI定位。面板代表2例受试者的三叉神经束造影（白色）和近端脑桥节段的ROI放置（红色）。纤维束叠加在共同登记的半透明T1加权解剖和基础扩散张量图像上。扩散张量图像按方向着色（红色，左-右；绿色，前-后；蓝色，上-下）(左图）箭头表示三叉神经的根进入区，在那里纤维束造影是从(右图）支架表示脑干三叉

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2021-10-29 cmj8wellington

#微结构#

84 0
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2022-03-23 小华子

#三叉神经#

98 0
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2021-06-30 yangeasy

#三叉神经痛#

69 0
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2021-06-30 stfoxst

#神经纤维#

93 0
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2021-06-30 贵阳

#神经痛#

103 0
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2021-06-28 沈楠

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