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CLIN CHEM LAB MED:降钙素原在区分隐源性组织肺炎和社区获得性肺炎中的应用

2019-11-17 MedSci MedSci原创

本研究旨在探讨炎症性生物标志物如白细胞(WBC)计数、c -反应蛋白(CRP)和降钙素原(PCT)在区分隐源性组织肺炎(COP)和社区获得性肺炎(CAP)中的作用。

本研究旨在探讨炎症性生物标志物如白细胞(WBC)计数、c -反应蛋白(CRP)和降钙素原(PCT)在区分隐源性组织肺炎(COP)和社区获得性肺炎(CAP)中的作用。

回顾性调查20101月至201712月在Kurashiki中心医院住院的COP患者的WBC计数、CRPPCT水平,并将其结果与201010月至201711月前瞻性纳入的CAP患者的结果进行比较。将COP定义为特异性的组织病理学,可能的COP定义为在无特异性组织病理学发现或肺标本的情况下,胸部ct上的实变影和支气管肺泡灌洗液中淋巴细胞优势。通过ROC曲线分析,评价WBC计数、CRPPCT的鉴别能力。

COP组共有56例病例,确证COP 35(61.4%)CAP 914例。三种生物标志物在COP中的AUC均显著低于CAPPCT在所有COP患者中的AUC均为0.79,显著高于CRP (AUC 0.59, p < 0.001)WBC (AUC 0.69, p = 0.048)。在确证的COP患者中,PCTAUC值为0.79,显著高于WBC (AUC 0.64, p = 0.006)CRP (AUC 0.64, p = 0.001)

研究表明,PCT是一种比WBC计数或CRP更有用的区分COPCAP的生物标志物。PCT应该作为临床表现和放射学发现的辅助手段。

原始出处:

Akihiro ItoTadashi IshidaUtility of procalcitonin for differentiating cryptogenic organising pneumonia from community-acquired pneumonia

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