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Detection and functional characterization of a novel MEF2A variation responsible for familial dilated cardiomyopathy

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2021; 59 (5)

Objectives: Dilated cardiomyopathy (DCM) represents the most frequent form of cardiomyopathy, leading to heart failure, cardiac arrhythmias and death.......

IFCC interim guidelines on rapid point-of-care antigen testing for SARS-CoV-2 detection in asymptomatic and symptomatic individuals

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2021; 59 (9)

With an almost unremittent progression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections all around the world, there is a com......

Using machine learning to identify clotted specimens in coagulation testing

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2021; 59 (7)

Objectives: A sample with a blood clot may produce an inaccurate outcome in coagulation testing, which may mislead clinicians into making improper cli......

Association of hemoglobin H (HbH) disease with hemoglobin A(1c) and glycated albumin in diabetic and non-diabetic patients

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2021; 59 (6)

Objectives: Hemoglobin A(1c) (HbA(1c)) and glycated albumin (GA) are glycemic control status indicators in patients with diabetes mellitus. Hemoglobin......

Recommendations for proficiency testing criteria for hemoglobin A1c based on the Shanghai Center for Clinical Laboratory's study

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2021; 59 (10)

Objectives: The US Centers for Medicare & Medicaid Services proposed in 2019 that glycated hemoglobin A1c (HbA1c) be a CLIA'88 regulated analyte. ......

The assessment of circulating cell-free DNA as a diagnostic tool for breast cancer: an updated systematic review and meta-analysis of quantitative and qualitative ssays

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2021; 59 (9)

Objectives: This updated meta-analysis aimed to assess the diagnostic accuracy of circulating cell-free DNA (cfDNA) in breast cancer (BC). Content: An......

Urinary exosomal CD26 is associated with recovery from acute kidney injury in intensive care units: a prospective cohort study

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2021; 59 (9)

Objectives: Currently there is no validated method to predict renal reversal and recovery after acute kidney injury (AKI). As exosomes have the potent......

Serum N-glycan fingerprint nomogram predicts liver fibrosis: a multicenter study

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2021; 59 (6)

Objectives: Liver cirrhosis (LC) is the end-stage of fibrosis in chronic liver diseases, non-invasive early detection of liver fibrosis (LF) is partic......

Using machine learning to develop an autoverification system in a clinical biochemistry laboratory

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2021; 59 (5)

Objectives: Autoverification systems have greatly improved laboratory efficiency. However, the long-developed rule-based autoverfication models have l......

Potential of MALDI-TOF mass spectrometry to overcome the interference of hemoglobin variants on HbA(1c) measurement

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2021; 59 (1)

Objectives: Hemoglobin (Hb) variants remain an important cause of erroneous HbA(1c) results. We present an approach to overcome the interference of Hb......

Hemoglobin variants in southern China: results obtained during the measurement of glycated hemoglobin in a large population

期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2021; 59 (1)

Objectives: Hemoglobin (Hb) variant is one of the most common monogenic inherited disorders. We aimed to explore the prevalence and hematological and ......

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