J Periodontal Res：2型糖尿病患者牙周炎和微血管病变之间的关系

2021-11-30 MedSci原创 MedSci原创

目前牙周炎是否会增加糖尿病微血管病变的风险仍有争议。近日，发表于J Periodontal Res的一项荟萃分析探究了2型糖尿病患者的牙周炎和糖尿病微血管病变之间的关系。

目前牙周炎是否会增加糖尿病微血管病变的风险仍有争议。近日，发表于J Periodontal Res的一项荟萃分析探究了2型糖尿病患者的牙周炎和糖尿病微血管病变之间的关系。

研究人员检索了PubMed、EMBASE、Web of Science、Cochrane图书馆、CNKI和万方数据。采用Newcastle-Ottawa量表法评估所纳入研究的方法学质量，并通过Review Manager 5.3进行荟萃分析。采用比值比（OR）和95%置信区间（CI）来评估2型糖尿病患者中牙周炎导致糖尿病微血管病变的风险。

结果，该项荟萃分析共纳入了13项横断面研究，涵盖10 570名参与者。分析结果显示，牙周炎与2型糖尿病微血管病变（OR：2.43，95% CI：1.65-3.56）、糖尿病视网膜病变（OR：4.33，95% CI：2.19-8.55）和糖尿病肾病（OR：1.75，95% CI：1.07-2.85）的风险增加有关，而牙周炎与糖尿病神经病变没有关系（OR：0.99，95% CI：0.19-5.12）。亚洲（OR：3.06，95% CI：1.94-4.84）和北美（OR：1.42，95% CI：1.08-1.86）人群的研究中的亚组分析证实了牙周炎和2型糖尿病微血管病变之间存在的关联。在样本量大于500（OR：1.77，95%CI：1.34-2.34）和小于500（OR：3.33，95%CI：1.38-8.03）的群体中，这种关联仍然存在。敏感性分析证实了结果的稳定性，即使排除了所有中等质量的研究，也得出了相同的结论（OR：1.73，95%CI：1.08-2.79，p = .02）。

综上所述，目前的证据已经证明，牙周炎与2型糖尿病患者的糖尿病微血管病变风险增加有关。这一结论可以为相关的临床研究提供有用的证据。

原始出处：

Xuexue Zhang,et al., Relationship between periodontitis and microangiopathy in type 2 diabetes mellitus: a meta-analysis. J Periodontal Res. 2021 Dec;56(6):1019-1027. doi: 10.1111/jre.12916.

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2022-05-18 feather89

#PE#

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2021-12-23 Luyuxie_17

#血管病#

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2021-12-01 mgqwxj

#微血管#

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2021-12-01 aids213

#2型糖尿病患者#

62 0
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2021-12-01 124987c6m36暂无昵称

#血管病变#

89 0
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2021-12-01 医者仁心

#牙周#

82 0
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2021-12-01 xue8604

#糖尿病患者#

68 0
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createdTime=Tue Nov 30 10:35:10 CST 2021, time=2021-11-30, status=1, ipAttribution=)]
2021-12-01 longqijun251

#微血管病变#

61 0
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createdTime=Tue Nov 30 10:35:10 CST 2021, time=2021-11-30, status=1, ipAttribution=)]
2021-11-30 ms6000000145764456

学习#糖尿病#

151 0

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