JCEM：糖尿病患者体重减轻，竟预示着死神来临？

2021-11-22 MedSci原创 MedSci原创

T2D发病后体重显著减轻与死亡率增加有关，尽管生活方式质量的改善减弱了这些关联。

近日，内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章，研究人员旨在探究2型糖尿病(T2D)参与者的体重变化与死亡率之间的关联，并评估采用健康生活方式对这种关联的影响。

这项前瞻性分析纳入了来自护士健康研究和健康专业人员随访研究的11262名T2D患者。研究人员评估了与死亡率相关的T2D诊断的体重变化。研究人员还分析了健康生活方式的潜在影响，包括高质量的饮食、规律的体育锻炼、不吸烟和适度饮酒。

一般而言，T2D患者在跨越T2D诊断的两年时间窗内体重减重了2.3kg，之后体重增加的轨迹与非糖尿病患者相似。

与体重稳定的患者相比，体重减轻10%以上的T2D患者的全因死亡率增加了21%(95%CI为9%-35%)。生活方式显著改变了这些关联：在生活方式恶化的参与者中，将体重减轻≥10%的患者与体重稳定的患者相比，对于生活方式恶化的参与者全因死亡率的风险比(95%CI)为1.63(1.26-2.09)，对于稳定的生活方式的患者为1.27(1.11-1.46)，对于生活方式改善的患者为1.02(0.81-1.27)（相互主要P<0.001）。主要的体重减轻与特定原因死亡率的增加有关，并且还观察到生活方式的类似的效应改变。

由此可见，T2D发病后体重显著减轻与死亡率增加有关，尽管生活方式质量的改善减弱了这些关联。这些结果强调了对新诊断的T2D患者采取健康生活方式的作用，尤其是那些可能无意减肥的患者，并提高其长期生存率。

原始出处：

Jinbo Hu.et al.Weight Change, Lifestyle and Mortality in Patients with Type 2 Diabetes.JCEM.2021.https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgab800/6422554

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2022-01-18 仁者大医

#JCEM#

69 0
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2022-05-03 achengzhao

#JCE#

64 0
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2021-12-26 cryhigher

学习了

0 0
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2021-12-25 马全萍

👍👍

82 0
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2021-12-09 1207866fm50(暂无昵称)

学习了

93 0
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2021-12-04 Lqqqqqqccc

学习

98 0
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2021-11-26 419040982

但感觉大部分体重下降不明显！除急病晚期

93 0
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2021-11-24 whlxd

#体重减轻#

68 0
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2021-11-24 xue8604

#糖尿病患者#

60 0
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2021-11-24 ms7000002126205048

学习了

99 0

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JCEM：糖尿病患者体重减轻，竟预示着死神来临？

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