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Prostate Cancer P D:疼痛在去势敏感性前列腺癌中的预后价值

2020-08-05 AlexYang MedSci原创

通常与骨转移有关的癌症疼痛在前列腺患者中是一种常见的使人衰弱的发病现象。到目前为止,关于疼痛在去势敏感性前列腺癌(mCSPC)男性中的预后价值数据很有限。最近,有研究人员评估了疼痛作为mCSPC患者独

通常与骨转移有关的癌症疼痛在前列腺患者中是一种常见的使人衰弱的发病现象。到目前为止,关于疼痛在去势敏感性前列腺癌(mCSPC)男性中的预后价值数据很有限。最近,有研究人员评估了疼痛作为mCSPC患者独立预后因子的情况。

研究是一个回顾性的分析,涉及了意大利的6个肿瘤中心的mCSPC患者。研究总共包括了365个病例相关数据,疼痛在34.8%的患者中出现。研究结果表明,疼痛主要与高水平的前列腺特异性抗原,不考虑位点的骨转移扩张和淋巴结转移相关。大多数出现疼痛的mCSPC患者具有高容量或者Hr疾病,且总生存(OS)(27.0个月 vs. 58.2个月, p<0.001) 和PFS (10.1个月 vs. 17.4个月, p<0.001))显著更短。在调整了CHAARTED或者LAITTUDE分类以及其他显著的极限预后因素后,疼痛对OS的负面影响仍旧保持显著。

有无疼痛时的总生存

ADT治疗下,接受(A)和不接受(B)多烯紫杉醇治疗患者在疼痛有无时的PFS

最后,研究人员指出,他们的分析支持了癌症相关的疼痛在mCSPC患者中作为不良预后因子的角色。然而,仍旧需要前瞻性的验证研究。

原始出处:

Roberto Iacovelli, Chiara Ciccarese, Orazio Caffo et al. The prognostic value of pain in castration-sensitive prostate cancer. Prostate Cancer P D. July 2020

 

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    2020-08-07 lsndxfj
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1791625, encodeId=9dc91e91625e1, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Fri Jan 01 14:12:28 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364638, encodeId=ba98136463813, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Fri Aug 07 05:12:28 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385242, encodeId=54f51385242a0, content=<a href='/topic/show?id=dc121001e22d' target=_blank style='color:#2F92EE;'>#预后价值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100172, encryptionId=dc121001e22d, topicName=预后价值)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70fe497, createdName=paperyu, createdTime=Fri Aug 07 05:12:28 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388520, encodeId=1a3713885201c, content=<a href='/topic/show?id=7ef25e5346b' target=_blank style='color:#2F92EE;'>#敏感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57534, encryptionId=7ef25e5346b, topicName=敏感性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJnkE6UvGFfMS41qV0RicWvVTTeLMicqibeZH5GqO4YhNicyl1Y9jFhylIUBn9ntPYy9jhk5hrfic5cRYw/132, createdBy=5f822500020, createdName=ms5236388012055669, createdTime=Fri Aug 07 05:12:28 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602292, encodeId=6d861602292f6, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Aug 07 05:12:28 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806500, encodeId=93d380650012, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Thu Aug 06 12:32:28 CST 2020, time=2020-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806366, encodeId=667180636616, content=<a href='/topic/show?id=c8ee32526f3' target=_blank style='color:#2F92EE;'>#前列腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32526, encryptionId=c8ee32526f3, topicName=前列腺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Aug 05 18:05:47 CST 2020, time=2020-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040803, encodeId=5c7a1040803e7, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Aug 05 17:12:28 CST 2020, time=2020-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806329, encodeId=03b68063299d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Wed Aug 05 15:18:07 CST 2020, time=2020-08-05, status=1, ipAttribution=)]
    2020-08-07 sunylz
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    2020-08-06 ms3000000449926787

    学习

    0

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    2020-08-05 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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    2020-08-05 ms3000000449926787

    学习

    0

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