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Clin Gastroenterology H:消除食物中牛奶蛋白成分的饮食模式可有效治疗儿童嗜酸性食管炎的症状

2021-04-22 MedSci原创 MedSci原创

嗜酸性食管炎(EoE)是一种慢性的由异种抗原介导的过敏性炎性疾病,有研究显示嗜酸性食管炎(EoE)中嗜酸性粒细胞明显增多。

      嗜酸性食管炎(EoE)是一种慢性的由异种抗原介导的过敏性炎性疾病,有研究显示嗜酸性食管炎(EoE)中嗜酸性粒细胞明显增多,而牛奶蛋白(CMP)是嗜酸性粒细胞性食管炎(EoE)患儿和成人发病的最常见诱因。因此,本项研究旨在评估当消除饮食中所有含CMP后的饮食饮食再缓解EoE的临床症状,内镜和组织学表现的效果。

 

      研究人员对接受消除饮食中所有CMP的单一食物饮食模式(1FED)治疗的EoE儿童进行了一项前瞻性观察研究。注册营养师对儿童及其看护者进行了有关饮食疗法的宣教,以消除所有含CM蛋白的食物,并通过替代来满足营养需求,以实现最佳生长和发育,并制定每日膳食计划。所有患者在治疗8-12周后进行消化道内镜检查。主要观察终点是组织学缓解,组织学缓解的定义为每个高倍视野少于15个嗜酸性粒细胞(eos / hpf)。次要观察终点是患者的临床症状,内镜和生活质量(QOL)的改善。

 

 

      共有41名儿童(男孩占76%)进行了1FED实验并接受了内窥镜检查。组织学缓解发生在21名(51%)儿童中,峰值eos / hpf从50降至1(p <0.0001)。内窥镜检查异常的患者有24例(59%),症状改善了25例(61%)。症状改善包括胸痛减轻,吞咽顺畅和呕吐的减少。同时孩子们大都觉得使用1FED可以改善生活质量。

图:独特饮食模式对于嗜酸性食管炎炎症的影响

      本项研究证实从饮食中消除含有CMP的食物的单一食物饮食模式可诱导50%以上的EoE儿童获得组织学缓解,并缓解临床症状和内窥镜异常。

 

 

原始出处:

Joshua B. Wechsler. Et al. A Single Food Milk Elimination Diet is Effective for Treatment of Eosinophilic Esophagitis in Children. Clinical Gastroenterology and Hepatology.2021.

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  4. 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    2021-08-20 许安
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    2021-04-24 yhy100201
  7. 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status=1, ipAttribution=)]
    2021-04-24 zhouqu_8
  8. 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  9. 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