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惊恐!异常进食竟会导致皮肤晒伤甚至皮肤癌!

2017-09-02 佚名 转化医学网

近日,美国西南医学中心的Peter O'Donnell Jr.脑研究所和加州大学欧文分校科学家通过小鼠试验表明,异常时间进食会破坏皮肤的生物钟,导致白天皮肤对紫外线的防御能力大幅下降。该研究对应文章则发表于最新上线的Cell Reports杂志。 尽管需要进一步研究加以证实这一结果,但这一发现仍在一定程度上表明深夜进食的人们可能更容易被紫外线晒伤或受到更为长期的消极影响,如加速皮肤老化或

近日,美国西南医学中心的Peter O'Donnell Jr.脑研究所和加州大学欧文分校科学家通过小鼠试验表明,异常时间进食会破坏皮肤的生物钟,导致白天皮肤对紫外线的防御能力大幅下降。该研究对应文章则发表于最新上线的Cell Reports杂志。
 
尽管需要进一步研究加以证实这一结果,但这一发现仍在一定程度上表明深夜进食的人们可能更容易被紫外线晒伤或受到更为长期的消极影响,如加速皮肤老化或提高皮肤癌发病风险等。
 


研究表明,相比于在白天正常时段喂食的小鼠,在夜间异常时段进行喂食的小鼠白天暴露于紫外线B(UVB)下会产生更多的皮肤损伤。研究人员表示,主要负责修复皮肤细胞紫外线损伤的干性皮肤色素A(XPA)酶系在小鼠异常时段喂食的前题下会发生一定程度的功能衰退。
 
而仅在正常傍晚时间喂食的小鼠却并没有显示出XPA功能周期的改变,对日间紫外线也没有显得像异常时段喂食小鼠那样敏感。
 
“如果你只是在正常的进食时间进食,那么你的皮肤将在白天更好地抵御紫外线的侵袭。”文章的主要作者Takahashi博士表示,“如果你在诸如午夜等异常的时段大量进食,那么你的皮肤生物钟就可能发生和研究中小鼠相似的改变。”
 
虽然先前的研究已经证实了人体皮肤生物学中昼夜节律的强大作用。但是很少有人尝试阐明生物钟影响皮肤生物学的具体方式。
 
同时,这项研究还发现除了能够打破XPA酶系的正常功能周期,改变饮食时间也可能会影响约10%皮肤基因的表达。
 
即便如此,研究人员仍然表示还需要更多的研究来更好地阐明人们饮食习惯与紫外线损伤之间的联系,特别是XPA功能周期受到影响的具体方式。
 
“目前,我们很难肯定这些现象同样存在于人类身上。但是,皮肤对食物摄入具体时间的敏感反应确实令我们着迷。”文章的作者表示。
 
原始出处:


Hong Wang et al. Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage, Cell Reports (2017). DOI: 10.1016/j.celrep.2017.07.022


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    2017-09-06 三生有幸9135

    学习一下谢谢分享

    0

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    2017-09-04 gj0737
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    2017-09-04 luominglian113

    学习了.谢谢分享

    0

  4. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240067, encodeId=9aea24006e43, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/xMb6ZO3ywuq1qDlj8Y9s89QX3uvsBJvYqKK0Z97KUgianMia4mN9icEIkvGvoJDNpDbqXpsEst3SjRcecS8OdhFbg/0, createdBy=3b911925301, createdName=The one 00000, createdTime=Sun Sep 03 16:49:32 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240006, encodeId=3dc52400062c, content=异常时间进食会破坏皮肤的生物钟.导致白天皮肤对紫外线的防御能力大幅下降., beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sun Sep 03 09:57:43 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239999, encodeId=47ce23999904, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Sep 03 09:00:19 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239986, encodeId=19b12399869f, content=希望对皮肤癌治疗有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2017-09-03 'sandra

    挺有意思的

    0

  5. 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    2017-09-03 The one 00000

    学习

    0

  6. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4Cr8ibeWnmTmmC1lthicNVicicXTX7Mn9OEib5S1eHg4jhM9usWmW2NBVm6NaJurhgeMl3UJ1gujuaQuIX7icVSa8F4JoFPCfib0Prsk/0, createdBy=b5bb2069360, createdName=cherry bomb, createdTime=Sun Sep 03 08:01:53 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-03 随梦飞扬

    异常时间进食会破坏皮肤的生物钟.导致白天皮肤对紫外线的防御能力大幅下降.

    0

  7. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4Cr8ibeWnmTmmC1lthicNVicicXTX7Mn9OEib5S1eHg4jhM9usWmW2NBVm6NaJurhgeMl3UJ1gujuaQuIX7icVSa8F4JoFPCfib0Prsk/0, createdBy=b5bb2069360, createdName=cherry bomb, createdTime=Sun Sep 03 08:01:53 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-03 明月清辉

    谢谢分享.学习了

    0

  8. 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createdName=随梦飞扬, createdTime=Sun Sep 03 09:57:43 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239999, encodeId=47ce23999904, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Sep 03 09:00:19 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239986, encodeId=19b12399869f, content=希望对皮肤癌治疗有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4Cr8ibeWnmTmmC1lthicNVicicXTX7Mn9OEib5S1eHg4jhM9usWmW2NBVm6NaJurhgeMl3UJ1gujuaQuIX7icVSa8F4JoFPCfib0Prsk/0, createdBy=b5bb2069360, createdName=cherry bomb, createdTime=Sun Sep 03 08:01:53 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-03 flysky120

    希望对皮肤癌治疗有帮助

    0

  9. 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createdName=随梦飞扬, createdTime=Sun Sep 03 09:57:43 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239999, encodeId=47ce23999904, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Sep 03 09:00:19 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239986, encodeId=19b12399869f, content=希望对皮肤癌治疗有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4Cr8ibeWnmTmmC1lthicNVicicXTX7Mn9OEib5S1eHg4jhM9usWmW2NBVm6NaJurhgeMl3UJ1gujuaQuIX7icVSa8F4JoFPCfib0Prsk/0, createdBy=b5bb2069360, createdName=cherry bomb, createdTime=Sun Sep 03 08:01:53 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-03 Y—xianghai

    学习了新知识

    0

  10. 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    2017-09-03 cherry bomb

    目前确实越来越多的人因为工作问题而饮食不规律

    0

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梅奥诊所研究发现,运动障碍帕金森病患者的皮肤癌黑色素瘤风险高得多,反之亦然。作者说,尽管需要进一步研究,但治疗一种疾病的医生应该警惕对方的迹象,并就这些患者的风险提供咨询。研究结果发表在Mayo Clinic Proceedings。

Environ Health Perspect:研究发现导致恶性皮肤癌的又一个潜在隐患因子!

氡是发展肺癌的危险因素是无可争议的。瑞士热带和公共卫生研究所(瑞士TPH)在瑞士国家队列研究的背景下进行的新研究显示,家庭内天然存在的放射性气体氡气也增加了发生恶性皮肤癌(恶性黑色素瘤)的风险。

PLoS Pathog:新机制的发现为抗击皮肤癌铺平道路

科学家已经确定了一些分子途径,某些类型的人乳头状瘤病毒(HPV)可能会增加皮肤癌的风险,特别是在罕见遗传性疾病表皮发育不良(EV)的人群中。 《PLOS病原体》描述了新的途径。

SCI REP:多吃西红柿可减少皮肤癌的发展

俄亥俄州立大学(Ohio State University)的一项动物实验研究表明,每日摄入番茄可以降低小鼠皮肤癌肿瘤的发展。《科学报告》杂志在线刊登了一项关于营养干预如何改变皮肤癌风险的新研究。研究发现,给雄性老鼠每天喂食10%的番茄粉,持续35周,然后将其曝露在紫外线下,与不吃脱水番茄的老鼠相比,实验组的皮肤癌肿瘤平均减少了50%。番茄和癌症之间的关系的理论解释是,膳食类胡萝卜素,赋予番茄颜色

Br J Dermatol:酒精摄入量与非黑素瘤皮肤癌的风险相关(Meta分析)

皮肤癌主要包括鳞状细胞癌、基底细胞癌、Bowen病、Paget病、恶性黑色素瘤五大类,以前两者为最多见。在美国,皮肤癌是最常见的癌症,而在我国,皮肤癌发病率较低,对治疗方法的探讨及认识相应较西方发达国家落后。近年来,随着皮肤癌发病率的上升,对该类疾病早期诊断和及时采取有效的的措施进行治疗越来越受到学术界的重视。非黑素瘤性皮肤癌(Nonmelanoma skin cancer,NMSC)主要包括基底

J Am Acad Dermatol:临床医生需警惕——异体造血干细胞移植后,使用伏立康唑会增加皮肤鳞状细胞癌风险

既往的研究发现:皮肤癌是实体器官移植后最常见的恶性肿瘤,其中以皮肤鳞状细胞癌(SCC)最为常见,发生率为一般人群的65倍,患者的死亡风险亦增高52倍,随着移植后生存时间的延长其发病率逐渐增加。很多因素增加器官移植患者发生皮肤癌的危险性。近来,有多个对伏立康唑的应用与肺移植患者发生SCC的相关性报道。造血干细胞移植(HCT)患者常使用伏立康唑作为真菌感染的二级预防,但很少有研究探讨伏立康唑的使用对皮

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