Stroke：MR CLEAN中装置选择对急性缺血性卒中动脉内治疗效果的影响

2016-09-19 MedSci MedSci原创

研究背景和研究目的：通过可回收支架进行动脉内治疗已经被证实是安全和有效的。在MR CLEAN（荷兰急性缺血性卒中血管内治疗的多中心随机临床试验）中，血栓摘除装置种类的选择由术者自行决定。这项研究旨在探究支架类型和构造对功能预后，神经功能恢复，再灌注，梗死的范围及不良事件发生的影响。研究方法：主要结局是根据改良Rankin量表（mRS）评估的90天功能结局。神经影像结局包括24小时CT血管造

研究背景和研究目的：通过可回收支架进行动脉内治疗已经被证实是安全和有效的。在MR CLEAN（荷兰急性缺血性卒中血管内治疗的多中心随机临床试验）中，血栓摘除装置种类的选择由术者自行决定。这项研究旨在探究支架类型和构造对功能预后，神经功能恢复，再灌注，梗死的范围及不良事件发生的影响。

研究方法：主要结局是根据改良Rankin量表（mRS）评估的90天功能结局。神经影像结局包括24小时CT血管造影显示的大血管闭塞，5到7天的梗死体积及梗死核心的血栓溶解。安全性结局包括90天内死亡和任何症状性颅内出血。我们使用多元回归分析了支架类型和治疗效果可能的相互关系。对疗效进行了病人年龄，卒中严重程度和侧枝评分的校正。

研究结果：在本试验纳入的500位病人中，233例进行了干预。这些中， 12例4 (53%)首先使用 Trevo（ mRS转变的调整OR[acOR, 1.98; 95% 置信区间, 1.30–2.92]）， 31 例(13%)使用 Solitaire(acOR, 1.90; 95% 置信区间, 0.97–3.73),40例 (17%）使用别的可回收支架或机械装置(acOR, 0.96; 95% confidence interval, 0.51–3.93], 38例 (16%)未完成治疗。装置选择对功能结局以及别的次级结局和安全性结局上而言的治疗效果上没有影响。

研究结论：我们没有发现不同支架种类对急性缺血性卒中取栓有影响的证据。

原始出处：

Dippel DW1, Majoie CB2, Roos YB2, van der Lugt A2,et al,Influence of Device Choice on the Effect of Intra-Arterial Treatment for Acute Ischemic Stroke in MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands).Stroke. 2016 Sep 6. pii: STROKEAHA.116.013929. [Epub ahead of print]

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2016-12-07 jxrzshh

#治疗效果#

72 0
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2016-11-16 12498da4m32(暂无昵称)

#缺血性卒#

76 0
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2016-11-29 guihongzh

#缺血性#

60 0
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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160904/IMG57CC36902016A2425.jpg, createdBy=6eb91946814, createdName=飛鹰, createdTime=Wed Sep 21 19:34:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131502, encodeId=a53a131502c7, content=学习并分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160904/IMG57CC36902016A2425.jpg, createdBy=6eb91946814, createdName=飛鹰, createdTime=Tue Sep 20 17:10:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131358, encodeId=984613135819, content=学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSEB4Gw5zzMTFicSXpRPB29ZqXZWCwpKGlNQClGxQkM0V13y0nwwfOibuwhkgK3VibicMKbKcMSUzTzp/0, createdBy=e5131935950, createdName=1e0dde21m68(暂无匿称), createdTime=Tue Sep 20 07:26:00 CST 2016, time=2016-09-20, status=1, ipAttribution=)]
2017-03-28 bioon1

#CLEAN#

57 0
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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSEB4Gw5zzMTFicSXpRPB29ZqXZWCwpKGlNQClGxQkM0V13y0nwwfOibuwhkgK3VibicMKbKcMSUzTzp/0, createdBy=e5131935950, createdName=1e0dde21m68(暂无匿称), createdTime=Tue Sep 20 07:26:00 CST 2016, time=2016-09-20, status=1, ipAttribution=)]
2016-09-22 飛鹰

谢谢分享！

134 0
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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160904/IMG57CC36902016A2425.jpg, createdBy=6eb91946814, createdName=飛鹰, createdTime=Wed Sep 21 19:34:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131502, encodeId=a53a131502c7, content=学习并分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160904/IMG57CC36902016A2425.jpg, createdBy=6eb91946814, createdName=飛鹰, createdTime=Tue Sep 20 17:10:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131358, encodeId=984613135819, content=学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSEB4Gw5zzMTFicSXpRPB29ZqXZWCwpKGlNQClGxQkM0V13y0nwwfOibuwhkgK3VibicMKbKcMSUzTzp/0, createdBy=e5131935950, createdName=1e0dde21m68(暂无匿称), createdTime=Tue Sep 20 07:26:00 CST 2016, time=2016-09-20, status=1, ipAttribution=)]
2016-09-21 飛鹰

谢谢分享！

133 0
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2016-09-20 飛鹰

学习并分享

138 0
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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160904/IMG57CC36902016A2425.jpg, createdBy=6eb91946814, createdName=飛鹰, createdTime=Wed Sep 21 19:34:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131502, encodeId=a53a131502c7, content=学习并分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160904/IMG57CC36902016A2425.jpg, createdBy=6eb91946814, createdName=飛鹰, createdTime=Tue Sep 20 17:10:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131358, encodeId=984613135819, content=学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151005/IMG5612955936CFA7964.jpg, createdBy=18621654109, createdName=Guoxj3234, createdTime=Tue Sep 20 12:28:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131203, encodeId=6a1413120383, content=小样本数据不能以点盖面，需要更多大数据支撑！, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=014e108570, createdName=chenchuny, createdTime=Tue Sep 20 08:59:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131172, encodeId=61441311e22f, content=数据量太少，能得出显著差异的结论那得多大的差异才行啊？！, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSEB4Gw5zzMTFicSXpRPB29ZqXZWCwpKGlNQClGxQkM0V13y0nwwfOibuwhkgK3VibicMKbKcMSUzTzp/0, createdBy=e5131935950, createdName=1e0dde21m68(暂无匿称), createdTime=Tue Sep 20 07:26:00 CST 2016, time=2016-09-20, status=1, ipAttribution=)]
2016-09-20 Guoxj3234

学习起来

0 0
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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160904/IMG57CC36902016A2425.jpg, createdBy=6eb91946814, createdName=飛鹰, createdTime=Wed Sep 21 19:34:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131502, encodeId=a53a131502c7, content=学习并分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160904/IMG57CC36902016A2425.jpg, createdBy=6eb91946814, createdName=飛鹰, createdTime=Tue Sep 20 17:10:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131358, encodeId=984613135819, content=学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSEB4Gw5zzMTFicSXpRPB29ZqXZWCwpKGlNQClGxQkM0V13y0nwwfOibuwhkgK3VibicMKbKcMSUzTzp/0, createdBy=e5131935950, createdName=1e0dde21m68(暂无匿称), createdTime=Tue Sep 20 07:26:00 CST 2016, time=2016-09-20, status=1, ipAttribution=)]
2016-09-20 chenchuny

小样本数据不能以点盖面，需要更多大数据支撑！

122 0
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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160904/IMG57CC36902016A2425.jpg, createdBy=6eb91946814, createdName=飛鹰, createdTime=Wed Sep 21 19:34:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131502, encodeId=a53a131502c7, content=学习并分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160904/IMG57CC36902016A2425.jpg, createdBy=6eb91946814, createdName=飛鹰, createdTime=Tue Sep 20 17:10:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131358, encodeId=984613135819, content=学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151005/IMG5612955936CFA7964.jpg, createdBy=18621654109, createdName=Guoxj3234, createdTime=Tue Sep 20 12:28:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131203, encodeId=6a1413120383, content=小样本数据不能以点盖面，需要更多大数据支撑！, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=014e108570, createdName=chenchuny, createdTime=Tue Sep 20 08:59:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131172, encodeId=61441311e22f, content=数据量太少，能得出显著差异的结论那得多大的差异才行啊？！, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSEB4Gw5zzMTFicSXpRPB29ZqXZWCwpKGlNQClGxQkM0V13y0nwwfOibuwhkgK3VibicMKbKcMSUzTzp/0, createdBy=e5131935950, createdName=1e0dde21m68(暂无匿称), createdTime=Tue Sep 20 07:26:00 CST 2016, time=2016-09-20, status=1, ipAttribution=)]
2016-09-20 1e0dde21m68(暂无匿称)

数据量太少，能得出显著差异的结论那得多大的差异才行啊？！

60 0

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