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JACC:口服抗凝药不会降低血透房颤患者的栓塞风险

2020-02-06 不详 MedSci原创

长期血透的患者出血的风险会增高,尽管口服抗凝药(OACs)可以降低房颤患者卒中风险,但是随机临床试验会将血透的患者排除在外。本荟萃分析的目的旨在评估OACs对接受血透治疗的房颤患者的影响。本研究纳入分析了16个符合标准的观察性研究(N=71877),其中只有2个研究为直接OACs。与未服用抗凝药物相比,apixaban和华法林与卒中和全身性栓塞风险的降低不相关,5mg的apixaban可以降低患者

长期血透的患者出血的风险会增高,尽管口服抗凝药(OACs)可以降低房颤患者卒中风险,但是随机临床试验会将血透的患者排除在外。本荟萃分析的目的旨在评估OACs对接受血透治疗的房颤患者的影响。

本研究纳入分析了16个符合标准的观察性研究(N=71877),其中只有2个研究为直接OACs。与未服用抗凝药物相比,apixaban和华法林与卒中和全身性栓塞风险的降低不相关,5mg的apixaban可以降低患者的死亡风险,而服用华法林比apixaban和不服用抗凝药的出血风险更高。另外,达比加群和利伐沙班同样比apixaban和不服用抗凝药的出血风险更高。

研究结果显示,对于长期接受血透治疗的房颤患者,口服抗凝药不会降低血栓栓塞的风险,华法林、达比加群和利伐沙班比apixaban和不服用抗凝药的出血风险更高。

原始出处:

本文系梅斯医学(MedSci)原创编译整理,转载需授权


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    2020-09-14 hbwxf
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    2020-02-08 luwei02
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    2020-02-06 心介

    房颤,临床上碰到很多哦

    0

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