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J Neurol Neurosur Ps:虚弱、生活方式、遗传与痴呆风险

2021-12-29 MedSci原创 MedSci原创

虚弱与痴呆风险密切相关,并会影响归因于遗传因素的风险。虚弱应被视为痴呆症的一个重要的可改变的危险因素和痴呆症预防策略的目标,即使在具有高遗传风险的人群中也是如此。

随着人口老龄化,痴呆症患者的数量正在增加,从而导致家庭和社会经济加重。即便如此,一些高收入国家的老年痴呆症发病率已显著下降,这为通过保护性生活方式和环境改变降低痴呆症风险提供了希望。但在观察数据中尚不清楚坚持健康的生活方式是否会降低较高遗传风险的个体患痴呆症的风险。为了优化痴呆症预防策略,研究人员必须了解生活方式行为、虚弱和遗传之间的复杂关系。

近日,神经病学领域权威取杂志Journal Of Neurology Neurosurgery And Psychiatry上发表了一篇研究文章,研究人员探讨了虚弱指数、健康生活方式和多基因风险评分(均在研究开始时评估)与住院记录和死亡登记数据中记录到的全因痴呆事件之间的关系。

在基线时,该研究所分析受试者的平均年龄为64.1岁(SD=2.9),53%是女性。在1762名参与者中检测到了痴呆事件(中位随访时间=8.0年)。重度虚弱与痴呆风险增加相关,但与遗传风险无关(HR为3.68,95%CI为3.11至4.35)。

体弱介导了健康生活方式行为与痴呆风险之间44%的关系(间接影响HR为0.95,95%CI为0.95至0.96)。与低遗传风险和虚弱程度较轻的参与者相比,高遗传风险和严重虚弱的参与者患痴呆症的风险高出5.8倍(HR为5.81,95%CI为4.01至8.42)。较高的遗传风险对虚弱程度较轻的个体影响最大(HR为1.31,95%CI为1.22到1.40),但对严重虚弱的个体没有影响(HR为1.09,95%CI为0.92到1.28)。

由此可见,虚弱与痴呆风险密切相关,并会影响归因于遗传因素的风险。虚弱应被视为痴呆症的一个重要的可改变的危险因素和痴呆症预防策略的目标,即使在具有高遗传风险的人群中也是如此。

 

原始出处:

David D Ward.et al.Frailty, lifestyle, genetics and dementia risk.Journal Of Neurology Neurosurgery And Psychiatry.2021.https://jnnp.bmj.com/content/early/2021/12/14/jnnp-2021-327396.

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    2022-07-31 yinhl1978
  2. [GetPortalCommentsPageByObjectIdResponse(id=2001661, encodeId=bcde2001661eb, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Jul 31 10:25:12 CST 2022, time=2022-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316820, encodeId=28df1316820e1, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Fri Dec 31 03:25:12 CST 2021, time=2021-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364776, encodeId=6c251364e7640, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Fri Dec 31 03:25:12 CST 2021, time=2021-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1085538, encodeId=5fd91085538e2, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Wed Dec 29 19:19:08 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246622, encodeId=10db12466225f, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Wed Dec 29 15:25:12 CST 2021, time=2021-12-29, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2001661, encodeId=bcde2001661eb, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Jul 31 10:25:12 CST 2022, time=2022-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316820, encodeId=28df1316820e1, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Fri Dec 31 03:25:12 CST 2021, time=2021-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364776, encodeId=6c251364e7640, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Fri Dec 31 03:25:12 CST 2021, time=2021-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1085538, encodeId=5fd91085538e2, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Wed Dec 29 19:19:08 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246622, encodeId=10db12466225f, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Wed Dec 29 15:25:12 CST 2021, time=2021-12-29, status=1, ipAttribution=)]
    2021-12-31 lsndxfj
  4. [GetPortalCommentsPageByObjectIdResponse(id=2001661, encodeId=bcde2001661eb, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Jul 31 10:25:12 CST 2022, time=2022-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316820, encodeId=28df1316820e1, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Fri Dec 31 03:25:12 CST 2021, time=2021-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364776, encodeId=6c251364e7640, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Fri Dec 31 03:25:12 CST 2021, time=2021-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1085538, encodeId=5fd91085538e2, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Wed Dec 29 19:19:08 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246622, encodeId=10db12466225f, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Wed Dec 29 15:25:12 CST 2021, time=2021-12-29, status=1, ipAttribution=)]
    2021-12-29 yangchou

    好文章,谢谢分享。

    0

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    2021-12-29 neuro.Dr

    老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!

    0

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