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Neurology: DWI阳性小病灶在脑小血管病进展中的价值

2020-01-06 shaosai MedSci原创

目的:本研究旨在评估脑小血管病(SVD)中无症状性扩散加权成像阳性小病灶的发生率,验证其在MRI中SVD标识物起源的价值。

目的:本研究旨在评估脑小血管病(SVD)中无症状性扩散加权成像阳性小病灶的发生率,验证其在MRI中SVD标识物起源的价值。

方法:本研究共纳入了503例SVD患者。分析所有受试者的DWI图像来寻找DWI+病灶,利用T2-FLAIR、T1和T2*图像对DWI+病灶进行随访,观察其变化,评估DWI+病灶与每年SVD进展的相关性(白质异常高信号(WMH)、腔隙性脑梗死、微出血)。

结果,在1152次DWI检查中,共有39例患者检查DWI+病灶,39例共包含50处DWI+病灶。与无DWI+病灶的患者相比,具有DWI+病灶患者的年龄要高于无DWI+的患者(p = 0.025),高血压病史更为常见(p = 0.021),SVD标记物(白质异常高信号(WMH)、腔隙性脑梗死、微出血,所有 p < 0.001)负荷更大。在23例具有DWI+病灶随访中,14 (61%)进展为WMH,8 (35%)进展为空腔,1 (4%)显示不清。DWI+病灶与每年WMH体积增加、发生腔隙性脑梗死和微出血具有显着相关性(所有p < 0.001)。

本研究表明,超过3%的SVD患者会出现DWI+病灶。尽管DWI+病灶对SVD进展有影响,但其并不能完全解释SVD标记物负荷进展的问题,这还有其他非急性缺血性指标影响着SVD的进展。

原始出处:

Wiegertjes K, Ter Telgte A, Oliveira PB,et al.The role of small diffusion-weighted imaging lesions in cerebral small vessel disease.Neurology.DOI:10.1212/WNL.0000000000008364

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    2020-08-02 yinhl1978
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    2020-01-08 hyf028
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