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Stroke:血管内血栓切除术前后体温对大血管阻塞性卒中的影响

2020-02-27 xing.T MedSci原创

由此可见,在接受EVT治疗的大血管闭塞性卒中患者中,缺血期和缺血后期两个阶段的体温升高均与较差的临床预后相关。

对于缺血性卒中患者,体温与患者功能预后相关。但是,在卒中的缺血期和缺血后期,体温与患者预后之间的关系可能有所不同。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在明确大血管阻塞性卒中的血管内血栓切除术(EVT)之前或之后的体温是否与患者临床结局相关。

研究人员从前瞻性登记处确定了连续就诊的EVT患者。入院24小时内的体温测量分为EVT前和EVT后测量,分别用作大血管闭塞性卒中的缺血期和缺血后期的替代指标。主要结局是功能独立性,定义为在3个月时改良的Rankin量表评分为0、1或2。次要结局包括在3个月时的改良的Rankin量表评分变化、症状性脑出血和3个月时的死亡率。

该研究纳入了342名参与者(59%为男性,平均±SD年龄为65.6±15.7岁)。多变量logistic回归表明,EVT前体温升高(每升高1°C)是功能独立性降低(比值比[OR]为0.66 [95%CI为0.46-0.94];P=0.02)、较差的改良Rankin量表评分(OR为1.42 [95%CI为1.08-1.85];P=0.01)和增加的死亡率(OR为1.65 [95%CI为1.02-2.69];P=0.04)的独立预测因子。EVT后峰值体温(每升高1°C)是改良Rankin量表评分升高(OR为1.39 [95%CI为1.03-1.90];P=0.03)和较高的死亡率(OR为1.66[95%CI为1.04-2.67];P=0.03)的重要预测指标。

由此可见,在接受EVT治疗的大血管闭塞性卒中患者中,缺血期和缺血后期两个阶段的体温升高均与较差的临床预后相关。

原始出处:

William K. Diprose.et al.Impact of Body Temperature Before and After Endovascular Thrombectomy for Large Vessel Occlusion Stroke.stroke.2020.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.028160

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    2020-05-25 tomyang96
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    2020-03-01 kkunny
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    2020-02-28 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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