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Medicina:褪黑素辅助全身应用可改善伴牙周病的2型糖尿病患者的血糖控制

2021-08-11 MedSci原创 MedSci原创

有证据表明,褪黑激素可以改善糖尿病患者的牙周状况和血糖控制。近日,一项发表于Medicina的随机对照试验评估洗牙和根管治疗加上褪黑激素的辅助系统治疗对2型糖尿病和慢性牙周炎患者的牙周参数和血糖控制的

有证据表明,褪黑激素可以改善糖尿病患者的牙周状况和血糖控制。近日,一项发表于Medicina的随机对照试验评估洗牙和根管治疗加上褪黑激素的辅助系统治疗对2型糖尿病和慢性牙周炎患者的牙周参数和血糖控制的影响,结果证实褪黑激素可为伴牙周炎的2型糖尿病患者提供额外的治疗益处。

该研究共纳入54名伴有牙周炎的2型糖尿病患者,随机分配到研究组(n = 27,接受洗牙和根管治疗+褪黑激素治疗)或对照组(n = 27,接受洗牙和根管治疗+安慰剂治疗)。在基线和8周后评估了牙周参数(探诊深度-PD;临床附着丧失-CAL;探诊出血-BOP;和口腔卫生水平)和糖化血红蛋白(HbA1c)的水平。

 

结果显示,基线时,各组之间没有明显的差异,但在8周后的第二次评估中,与对照组相比,研究组的牙周参数和糖化血红蛋白水平方面都有明显的改善,牙周病严重程度明显下降

综上,该研究中,与仅非手术牙周治疗相比,联合非手术牙周治疗和褪黑激素全身治疗对伴有严重牙周病的2型糖尿病患者的血糖控制有额外改善。

原始出处:

Diana-Maria Anton, et al., Study on the Effects of Melatonin on Glycemic Control and Periodontal Parameters in Patients with Type II Diabetes Mellitus and Periodontal Disease. Medicina (Kaunas). 2021 Feb 5;57(2):140. doi: 10.3390/medicina57020140.

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    2022-10-11 lifestar

    #褪黑素#辅助全身应用可改善伴#牙周病##2型糖尿病#患者的#血糖控制#

    0

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    2022-01-07 jeanqiuqiu
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    2021-12-26 kalseyzl
  4. [GetPortalCommentsPageByObjectIdResponse(id=2093001, encodeId=61da20930014a, content=<a href='/topic/show?id=7b2a9045470' target=_blank style='color:#2F92EE;'>#褪黑素#</a>辅助全身应用可改善伴<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>的<a href='/topic/show?id=d20f1090c2' target=_blank style='color:#2F92EE;'>#2型糖尿病#</a>患者的<a href='/topic/show?id=2f468983351' target=_blank style='color:#2F92EE;'>#血糖控制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90454, encryptionId=7b2a9045470, topicName=褪黑素), TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病), TopicDto(id=1090, encryptionId=d20f1090c2, topicName=2型糖尿病), TopicDto(id=89833, encryptionId=2f468983351, topicName=血糖控制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Tue Oct 11 00:50:17 CST 2022, time=2022-10-11, status=1, ipAttribution=), 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createdName=kalseyzl, createdTime=Sun Dec 26 15:21:39 CST 2021, time=2021-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273046, encodeId=fcca12e304687, content=<a href='/topic/show?id=2f468983351' target=_blank style='color:#2F92EE;'>#血糖控制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89833, encryptionId=2f468983351, topicName=血糖控制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef84111, createdName=whlxd, createdTime=Fri Aug 13 11:21:39 CST 2021, time=2021-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282318, encodeId=0ae412823180e, content=<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67522, 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href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Aug 13 11:21:39 CST 2021, time=2021-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043729, encodeId=c77b1043e298f, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Aug 11 23:21:39 CST 2021, time=2021-08-11, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2093001, encodeId=61da20930014a, content=<a href='/topic/show?id=7b2a9045470' target=_blank style='color:#2F92EE;'>#褪黑素#</a>辅助全身应用可改善伴<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>的<a href='/topic/show?id=d20f1090c2' target=_blank style='color:#2F92EE;'>#2型糖尿病#</a>患者的<a href='/topic/show?id=2f468983351' target=_blank style='color:#2F92EE;'>#血糖控制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90454, encryptionId=7b2a9045470, topicName=褪黑素), TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病), TopicDto(id=1090, encryptionId=d20f1090c2, topicName=2型糖尿病), TopicDto(id=89833, encryptionId=2f468983351, topicName=血糖控制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Tue Oct 11 00:50:17 CST 2022, time=2022-10-11, status=1, ipAttribution=), 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createdName=kalseyzl, createdTime=Sun Dec 26 15:21:39 CST 2021, time=2021-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273046, encodeId=fcca12e304687, content=<a href='/topic/show?id=2f468983351' target=_blank style='color:#2F92EE;'>#血糖控制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89833, encryptionId=2f468983351, topicName=血糖控制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef84111, createdName=whlxd, createdTime=Fri Aug 13 11:21:39 CST 2021, time=2021-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282318, encodeId=0ae412823180e, content=<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Fri Aug 13 11:21:39 CST 2021, time=2021-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383708, encodeId=a5e21383e08cf, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Aug 13 11:21:39 CST 2021, time=2021-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451361, encodeId=0b5b14513619a, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, 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href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Aug 13 11:21:39 CST 2021, time=2021-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043729, encodeId=c77b1043e298f, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Aug 11 23:21:39 CST 2021, time=2021-08-11, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2093001, encodeId=61da20930014a, content=<a href='/topic/show?id=7b2a9045470' target=_blank style='color:#2F92EE;'>#褪黑素#</a>辅助全身应用可改善伴<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>的<a href='/topic/show?id=d20f1090c2' target=_blank style='color:#2F92EE;'>#2型糖尿病#</a>患者的<a href='/topic/show?id=2f468983351' target=_blank style='color:#2F92EE;'>#血糖控制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90454, encryptionId=7b2a9045470, topicName=褪黑素), TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病), TopicDto(id=1090, encryptionId=d20f1090c2, topicName=2型糖尿病), TopicDto(id=89833, encryptionId=2f468983351, topicName=血糖控制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Tue Oct 11 00:50:17 CST 2022, time=2022-10-11, status=1, ipAttribution=), 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encryptionId=46a06e5220c, topicName=牙周病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Fri Aug 13 11:21:39 CST 2021, time=2021-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383708, encodeId=a5e21383e08cf, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Aug 13 11:21:39 CST 2021, time=2021-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451361, encodeId=0b5b14513619a, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Fri Aug 13 11:21:39 CST 2021, time=2021-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475114, encodeId=fd2b14e511413, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 13 11:21:39 CST 2021, time=2021-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611216, encodeId=9cac161121634, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Aug 13 11:21:39 CST 2021, time=2021-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043729, encodeId=c77b1043e298f, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Aug 11 23:21:39 CST 2021, time=2021-08-11, status=1, ipAttribution=)]
  7. 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GetPortalCommentsPageByObjectIdResponse(id=1859182, encodeId=0ab1185918283, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Fri Jan 07 14:21:39 CST 2022, time=2022-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773985, encodeId=f35b1e73985a3, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Sun Dec 26 15:21:39 CST 2021, time=2021-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273046, encodeId=fcca12e304687, content=<a href='/topic/show?id=2f468983351' target=_blank style='color:#2F92EE;'>#血糖控制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89833, encryptionId=2f468983351, topicName=血糖控制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef84111, createdName=whlxd, createdTime=Fri Aug 13 11:21:39 CST 2021, time=2021-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282318, encodeId=0ae412823180e, content=<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Fri Aug 13 11:21:39 CST 2021, time=2021-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383708, encodeId=a5e21383e08cf, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Aug 13 11:21:39 CST 2021, time=2021-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451361, encodeId=0b5b14513619a, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, 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  8. [GetPortalCommentsPageByObjectIdResponse(id=2093001, encodeId=61da20930014a, content=<a href='/topic/show?id=7b2a9045470' target=_blank style='color:#2F92EE;'>#褪黑素#</a>辅助全身应用可改善伴<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>的<a href='/topic/show?id=d20f1090c2' target=_blank style='color:#2F92EE;'>#2型糖尿病#</a>患者的<a href='/topic/show?id=2f468983351' target=_blank style='color:#2F92EE;'>#血糖控制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90454, encryptionId=7b2a9045470, topicName=褪黑素), TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病), TopicDto(id=1090, encryptionId=d20f1090c2, topicName=2型糖尿病), TopicDto(id=89833, encryptionId=2f468983351, topicName=血糖控制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Tue Oct 11 00:50:17 CST 2022, time=2022-10-11, status=1, ipAttribution=), 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encryptionId=46a06e5220c, topicName=牙周病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Fri Aug 13 11:21:39 CST 2021, time=2021-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383708, encodeId=a5e21383e08cf, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Aug 13 11:21:39 CST 2021, time=2021-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451361, encodeId=0b5b14513619a, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, 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  9. 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  10. 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