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Expression level is a major modifier of the fitness landscape of a protein coding gene

Wu, ZX; Cai, XJ; Zhang, X; Liu, Y; Tian, GB; Yang, JR; Chen, XS

Yang, JR (通讯作者),Sun Yat Sen Univ, Zhongshan Sch Med, Dept Biomed Informat, Guangzhou, Peoples R China.;Chen, XS (通讯作者),Sun Yat Sen Univ, Zhongshan Sch Med, Dept Med Genet, Guangzhou, Peoples R China.;Yang, JR; Chen, XS (通讯作者),Sun Yat Sen Univ, Key Lab Trop Dis Control, Minist Educ, Guangzhou, Peoples R China.

NATURE ECOLOGY & EVOLUTION, 2022; 6 (1): 103

Abstract

The phenotypic consequence of a genetic mutation depends on many factors including the expression level of a gene. However, a comprehensive quantifica......

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