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Therapeutic Efficacy of Carbon Ion Irradiation Enhanced by 11-MUA-Capped Gold Nanoparticles: An in vitro and in vivo Study

期刊: INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021; 16 ()

Purpose: Gold nanoparticles (AuNPs) are widely studied as radiosensitizers, but their radio-sensitization in carbon ion radiotherapy is unsatisfactory......

The Stability of Dentin Surface Biobarrier Consisting of Mesoporous Delivery System on Dentinal Tubule Occlusion and Streptococcus Mutans Biofilm Inhibition

期刊: INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021; 16 ()

Background: The dentin exposure always leads to dentin hypersensitivity and/or caries. Given the dentin's tubular structure and low mineralization deg......

Smart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy

期刊: INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021; 16 ()

Dysfunction in the mitochondria (Mc) contributes to tumor progression. It is a major challenge to deliver therapeutic agents specifically to the Mc fo......

An Acceptor-pi-Donor Structured Organic Chromophore for NIR Triggered Thermal Ablation of Tumor via DNA Damage-Mediated Apoptosis

期刊: INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021; 16 ()

Introduction: It will be challenging to develop high-performance organic chromophores for light-triggered thermal ablation of the tumor. Besides, the ......

Nanobubbles Containing sPD-1 and Ce6 Mediate Combination Immunotherapy and Suppress Hepatocellular Carcinoma in Mice

期刊: INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021; 16 ()

Purpose: Immune checkpoint inhibitors (ICIs) and sonodynamic therapy (SDT) are types of immunotherapy. In order to combine soluble programmed cell dea......

Recent Advances in Macrophage-Mediated Drug Delivery Systems

期刊: INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021; 16 ()

Macrophages have been extensively used in the development of drug delivery systems, as they can prolong the circulation and release of drugs, extend t......

A Novel pH-Sensitive Multifunctional DNA Nanomedicine: An Enhanced and Harmless GD2 Aptamer-Mediated Strategy for Guiding Neuroblastoma Antitumor Therapy

期刊: INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021; 16 ()

Background: GD2 is a mainstream biomarker for neuroblastoma (NB)-targeted therapy. Current anti-GD2 therapeutics exhibit several side effects since GD......

Synergistic Therapy Using Doxorubicin-Loading and Nitric Oxide-Generating Hollow Prussian Blue Nanoparticles with Photoacoustic Imaging Potential Against Breast Cancer

期刊: INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021; 16 ()

Introduction: Traditional antitumor chemotherapy faces great challenges, such as multi-drug resistance (MDR) and poor penetration into tumor tissues. ......

Combination of Chemotherapy and Photodynamic Therapy with Oxygen Self-Supply in the Form of Mutual Assistance for Cancer Therapy

期刊: INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021; 16 ()

Introduction: Photodynamic therapy (PDT) has been widely researched by cancer therapists in recent years. This study aims to establish a drug delivery......

Au Nanoclusters Ameliorate Shigella Infectious Colitis by Inducing Oxidative Stress

期刊: INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021; 16 ()

Background: Shigella infection has always been a global burden, and it particularly threatens children between the ages of 1 and 5 years. Economically......

Nanohydroxyapatite, Nanosilicate-Reinforced Injectable, and Biomimetic Gelatin-Methacryloyl Hydrogel for Bone Tissue Engineering

期刊: INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021; 16 ()

Purpose: Given that autologous bone graft for bone defects is limited by insufficient supply and morbidity at the donor site, developing biomimetic gr......

Dual Modal Imaging-Guided Drug Delivery System for Combined Chemo-Photothermal Melanoma Therapy

期刊: INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021; 16 ()

Purpose: Malignant melanoma is one of the most devastating types of cancer with rapid relapse and low survival rate. Novel strategies for melanoma tre......

Surfactant Assisted Rapid-Release Liposomal Strategies Enhance the Antitumor Efficiency of Bufalin Derivative and Reduce Cardiotoxicity

期刊: INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021; 16 ()

Background: BF211, a derivative of bufalin (BF), shows significantly improved solubility and potent antitumor efficiency compared to BF. Unfortunately......

Targeting Antibacterial Effect and Promoting of Skin Wound Healing After Infected with Methicillin-Resistant Staphylococcus aureus for the Novel Polyvinyl Alcohol Nanoparticles

期刊: INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021; 16 ()

Introduction: Topical agents typically remain in the wound site for time duration that are too short to effectively eradicate MRSA tradition formation......

Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions

期刊: INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021; 16 ()

Extracellular vesicles (EVs), as nanoscale membranous vesicles containing DNAs, RNAs, lipids and proteins, have emerged as promising diagnostic and th......

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