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A small and highly sensitive red/far-red optogenetic switch for applications in mammals

期刊: NATURE BIOTECHNOLOGY, 2022; 40 (2)

Optogenetic technologies have transformed our ability to precisely control biological processes in time and space. Yet, current eukaryotic optogenetic......

JIF:15.133

Sparse deconvolution improves the resolution of live-cell super-resolution fluorescence microscopy

期刊: NATURE BIOTECHNOLOGY, 2022; 40 (4)

A main determinant of the spatial resolution of live-cell super-resolution (SR) microscopes is the maximum photon flux that can be collected. To furth......

JIF:15.133

Multi-omics single-cell data integration and regulatory inference with graph-linked embedding

期刊: NATURE BIOTECHNOLOGY, 2022; 40 (10)

Despite the emergence of experimental methods for simultaneous measurement of multiple omics modalities in single cells, most single-cell datasets inc......

JIF:15.133

Deep tissue multi-photon imaging using adaptive optics with direct focus sensing and shaping

期刊: NATURE BIOTECHNOLOGY, 2022; 40 (11)

High-resolution optical imaging deep in tissues is challenging because of optical aberrations and scattering of light caused by the complex structure ......

JIF:15.133

A fluorescent sensor for spatiotemporally resolved imaging of endocannabinoid dynamics in vivo

期刊: NATURE BIOTECHNOLOGY, 2022; 40 (5)

Endocannabinoids (eCBs) are retrograde neuromodulators with important functions in a wide range of physiological processes, but their in vivo dynamics......

JIF:15.133

Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins

期刊: NATURE BIOTECHNOLOGY, 2022; 40 (5)

Photoswitchable RNA-binding proteins enable the spatiotemporal control of RNA function. RNA-binding proteins (RBPs) play an essential role in regulati......

JIF:15.133

Integrative spatial analysis of cell morphologies and transcriptional states with MUSE

期刊: NATURE BIOTECHNOLOGY, 2022; 40 (8)

Deep learning analysis of microscopy and spatial transcriptomics data characterizes cell types and states. Spatial transcriptomics enables the simulta......

JIF:15.133

Towards the non-invasive imaging of brain networks and functions at high resolution

期刊: NATURE BIOTECHNOLOGY, 2022; 40 (11)

A new study describes a microscope combining three-photon excitation and adaptive optics capable of high-resolution in vivo imaging of fine neuronal s......

JIF:15.133

An engineered prime editor with enhanced editing efficiency in plants

期刊: NATURE BIOTECHNOLOGY, 2022; 40 (9)

Prime editing is a versatile genome-editing technology, but it suffers from low editing efficiency. In the present study, we introduce optimized prime......

JIF:15.133

Targeting a gene regulatory element enhances rice grain yield by decoupling panicle number and size

期刊: NATURE BIOTECHNOLOGY, 2022; 40 (9)

Crop genetic improvement requires balancing complex tradeoffs caused by gene pleiotropy and linkage drags, as exemplified by IPA1 (Ideal Plant Archite......

JIF:15.133

Directed evolution and selection of biostable l-DNA aptamers with a mirror-image DNA polymerase

期刊: NATURE BIOTECHNOLOGY, 2022; 40 (11)

Mirror-image aptamers made from chirally inverted nucleic acids are nuclease-resistant and exceptionally biostable, opening up opportunities for uniqu......

JIF:15.133

Generation of a live attenuated influenza A vaccine by proteolysis targeting

期刊: NATURE BIOTECHNOLOGY, 2022; 40 (9)

The usefulness of live attenuated virus vaccines has been limited by suboptimal immunogenicity, safety concerns or cumbersome manufacturing processes ......

JIF:15.133

A genome and gene catalog of glacier microbiomes

期刊: NATURE BIOTECHNOLOGY, 2022; 40 (9)

Glaciers represent a unique inventory of microbial genetic diversity and a record of evolution. The Tibetan Plateau contains the largest area of low-l......

JIF:15.133

m(6)A RNA modifications are measured at single-base resolution across the mammalian transcriptome

期刊: NATURE BIOTECHNOLOGY, 2022; 40 (8)

Functional studies of the RNA N-6-methyladenosine (m(6)A) modification have been limited by an inability to map individual m(6)A-modified sites in who......

JIF:15.133

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