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Time to infer miRNA sponge modules

期刊: WILEY INTERDISCIPLINARY REVIEWS-RNA, 2022; 13 (2)

Inferring competing endogenous RNA (ceRNA) or microRNA (miRNA) sponge modules is a challenging and meaningful task for revealing ceRNA regulation mech......

JIF:7.817

Evolutionary driving forces of A-to-I editing in metazoans

期刊: WILEY INTERDISCIPLINARY REVIEWS-RNA, 2022; 13 (1)

Adenosine-to-inosine (A-to-I) RNA editing is an evolutionarily conserved mechanism that converts adenosines to inosines in metazoans' transcriptomes. ......

JIF:7.817

Subcellular distribution, localization, and function of noncoding RNAs

期刊: WILEY INTERDISCIPLINARY REVIEWS-RNA, 2022; 13 (6)

Eukaryotic cells contain subcellular organelles with spatiotemporal regulation to coordinate various biochemical reactions. The various organelles per......

JIF:7.817

Potential applications of N-6-methyladenosine modification in the prognosis and treatment of cancers via modulating apoptosis, autophagy, and ferroptosis

期刊: WILEY INTERDISCIPLINARY REVIEWS-RNA, 2022; 13 (5)

N-6-methyladenosine (m(6)A) is one of the most abundant modifications determining the fate of RNA. Currently, m(6)A modification is tightly connected ......

JIF:7.817

PINTology: A short history of the lncRNA LINC-PINT in different diseases

期刊: WILEY INTERDISCIPLINARY REVIEWS-RNA, 2022; 13 (4)

LINC-PINT is a p53-induced long intergenic noncoding transcript that plays a crucial role in many diseases, especially cancer. This long noncoding RNA......

JIF:7.817

The regulatory role of N-6-methyladenosine modification in the interaction between host and microbes

期刊: WILEY INTERDISCIPLINARY REVIEWS-RNA, 2022; 13 (6)

N-6-methyladenosine (m(6)A) is the most prevalent posttranscriptional modification in eukaryotic mRNAs. Dynamic and reversible m(6)A modification regu......

JIF:7.817

Emerging roles of RNA-RNA interactions in transcriptional regulation

期刊: WILEY INTERDISCIPLINARY REVIEWS-RNA, 2022; 13 (5)

Pervasive transcription of the human genome generates a massive amount of noncoding RNAs (ncRNAs) that lack protein-coding potential but play crucial ......

JIF:7.817

Application of nucleoside or nucleotide analogues in RNA dynamics and RNA-binding protein analysis

期刊: WILEY INTERDISCIPLINARY REVIEWS-RNA, 2022; 13 (6)

Cellular RNAs undergo dynamic changes during RNA biological processes, which are tightly orchestrated by RNA-binding proteins (RBPs). Yet, the investi......

JIF:7.817

Computational methods for predicting hotspots at protein-RNA interfaces

期刊: WILEY INTERDISCIPLINARY REVIEWS-RNA, 2022; 13 (2)

Protein-RNA interactions play essential roles in many critical biological events. A comprehensive understanding of the mechanisms underlying these int......

JIF:7.817

Circular RNA in disease: Basic properties and biomedical relevance

期刊: WILEY INTERDISCIPLINARY REVIEWS-RNA, 2022; 13 (6)

Circular RNAs (circRNAs) represent a class of covalently closed RNA molecules with great diversity in molecular features, functions, and regulatory me......

JIF:7.817

Dynamic transcriptomic m(5)C and its regulatory role in RNA processing

期刊: WILEY INTERDISCIPLINARY REVIEWS-RNA, ; ()

RNA 5-methylcytosine (m(5)C) is a prevalent RNA modification in multiple RNA species, including messenger RNAs (mRNAs), transfer RNAs (tRNAs), ribosom......

Nanocarrier-delivered small interfering RNA for chemoresistant ovarian cancer therapy

期刊: WILEY INTERDISCIPLINARY REVIEWS-RNA, ; ()

Ovarian cancer is the fifth leading cause of cancer-related death in women in the United States. Because success in early screening is limited, and mo......

Single-cell RNA sequencing: A new opportunity for retinal research

期刊: WILEY INTERDISCIPLINARY REVIEWS-RNA, ; ()

Single-cell RNA sequencing (scRNA-seq) is a technology for single-cell transcriptome analysis that can be used to characterize complex dynamics of var......

Noncoding RNAs: New regulatory code in chondrocyte apoptosis and autophagy

期刊: WILEY INTERDISCIPLINARY REVIEWS-RNA, 2020; 11 (4)

Osteoarthritis (OA) is a bone and joint disease characterized by progressive cartilage degradation. In the face of global trends of population aging, ......

TRIM25 and its emerging RNA-binding roles in antiviral defense

期刊: WILEY INTERDISCIPLINARY REVIEWS-RNA, 2020; 11 (4)

The innate immune system is the body's first line of defense against viruses, with pattern recognition receptors (PRRs) recognizing molecules unique t......

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