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Structures of Foot-and-mouth Disease Virus with neutralizing antibodies derived from recovered natural host reveal a mechanism for cross-serotype neutralization

期刊: PLOS PATHOGENS, 2021; 17 (4)

The development of a universal vaccine against foot-and-mouth disease virus (FMDV) is hindered by cross-serotype antigenic diversity and by a lack of ......

A bacterial tyrosine phosphatase modulates cell proliferation through targeting RGCC

期刊: PLOS PATHOGENS, 2021; 17 (5)

Tyrosine phosphatases are often weaponized by bacteria colonizing mucosal barriers to manipulate host cell signal transduction pathways. Porphyromonas......

The degree of polymerization and sulfation patterns in heparan sulfate are critical determinants of cytomegalovirus entry into host cells

期刊: PLOS PATHOGENS, 2021; 17 (8)

Author summary Heparan sulfate (HS) is a linear polysaccharide (sugar) found in all animal tissues. It binds to a variety of protein ligands, includin......

The RNA helicase DDX5 promotes viral infection via regulating N-6-methyladenosine levels on the DHX58 and NF kappa B transcripts to dampen antiviral innate immunity

期刊: PLOS PATHOGENS, 2021; 17 (4)

Multi-functional DEAD-box helicase 5 (DDX5), which is important in transcriptional regulation, is hijacked by diverse viruses to facilitate viral repl......

Conservative production of galactosaminogalactan in Metarhizium is responsible for appressorium mucilage production and topical infection of insect hosts

期刊: PLOS PATHOGENS, 2021; 17 (6)

The exopolysaccharide galactosaminogalactan (GAG) has been well characterized in Aspergilli, especially the human pathogen Aspergillus fumigatus. It h......

EBV latent membrane proteins promote hybrid epithelial-mesenchymal and extreme mesenchymal states of nasopharyngeal carcinoma cells for tumorigenicity

期刊: PLOS PATHOGENS, 2021; 17 (8)

EBV-encoded LMPs are consistently detected in nasopharyngeal carcinoma (NPC). Recent evidence suggests potential roles of LMP1 and LMP2A in Epithelial......

Evolution of the interactions between GII.4 noroviruses and histo-blood group antigens: Insights from experimental and computational studies

期刊: PLOS PATHOGENS, 2021; 17 (7)

Author summary Human norovirus (NoV) has been recognized as the leading cause of the epidemic acute gastroenteritis worldwide and more than 50% acute ......

The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models

期刊: PLOS PATHOGENS, 2021; 17 (6)

Bovine spongiform encephalopathy (BSE) is a prion disease of cattle that is caused by the misfolding of the cellular prion protein (PrP(C)) into an in......

Host GRXC6 restricts Tomato yellow leaf curl virus infection by inhibiting the nuclear export of the V2 protein

期刊: PLOS PATHOGENS, 2021; 17 (8)

Author summary Geminiviruses infect numerous crops, induce a wide range of symptoms, and cause tremendous crop losses annually. Tomato yellow leaf cur......

Genetic and biological properties of H7N9 avian influenza viruses detected after application of the H7N9 poultry vaccine in China

期刊: PLOS PATHOGENS, 2021; 17 (4)

The H7N9 avian influenza virus (AIV) that emerged in China have caused five waves of human infection. Further human cases have been successfully preve......

Aryl hydrocarbon receptor activation by Lactobacillus reuteri tryptophan metabolism alleviates Escherichia coli-induced mastitis in mice

期刊: PLOS PATHOGENS, 2021; 17 (7)

The intestinal microbiota has been associated with the occurrence and development of mastitis, which is one of the most serious diseases of lactating ......

Sustained viremia suppression by SHIVSF162P3CN-recalled effector-memory CD8(+) T cells after PD1-based vaccination

期刊: PLOS PATHOGENS, 2021; 17 (6)

HIV-1 functional cure requires sustained viral suppression without antiretroviral therapy. While effector-memory CD8(+) T lymphocytes are essential fo......

Tropilaelaps mercedesae parasitism changes behavior and gene expression in honey bee workers

期刊: PLOS PATHOGENS, 2021; 17 (7)

Author summary In recent decades, there has been serious concern about the decline of honey bees in the world. One of the most serious factors contrib......

Mouse papillomavirus type 1 (MmuPV1) DNA is frequently integrated in benign tumors by microhomology-mediated end-joining

期刊: PLOS PATHOGENS, 2021; 17 (8)

Author summary Persistent high-risk HPV infection leads viral DNA integration into the host genome and promotes viral carcinogenesis. We have been usi......

Nine viruses from eight lineages exhibiting new evolutionary modes that co-infect a hypovirulent phytopathogenic fungus

期刊: PLOS PATHOGENS, 2021; 17 (8)

Mycoviruses are an important component of the virosphere, but our current knowledge of their genome organization diversity and evolution remains rudim......

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