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CircRNAs in Lung-intestinal Axis Cancer

期刊: CURRENT MOLECULAR MEDICINE, 2021; 21 (4)

The "exterior-interior relationship between the lung and the large intestine" is a basic theory in Traditional Chinese Medicine (TCM), which has been ......

= Heat Shock Proteins Regulating Toll-like Receptors and the Immune System could be a Novel Therapeutic Target for Melanoma

期刊: CURRENT MOLECULAR MEDICINE, 2021; 21 (1)

Melanoma is a serious type of skin cancer, which develops in melanocyte cells. Although it is less common than some other skin cancers, it can be far ......

The Antitumor Effects of Icaritin Against Breast Cancer is Related to Estrogen Receptors

期刊: CURRENT MOLECULAR MEDICINE, 2021; 21 (1)

Objective: We aim to investigate the anticancer effects and mechanisms of icaritin against breast cancer. Materials and Methods: Both estrogen recepto......

Active Immunotherapy with 12-mer A beta 1-42-like Assembly Vaccine Shows Efficacy in Aged 3xTg-AD Mice

期刊: CURRENT MOLECULAR MEDICINE, 2021; 21 (1)

Background: Alzheimer's disease (AD) is the most common progressive neurodegenerative disorder characterized by senile plaques and neurofibrillary tan......

The Melatonin and Enriched Environment Ameliorated Low Protein-Induced Intrauterine Growth Retardation by IGF-1 And mtor Signaling Pathway and Autophagy Inhibition in Rats

期刊: CURRENT MOLECULAR MEDICINE, 2021; 21 (3)

Aim: The present study investigated whether melatonin (MEL) and enriched environment (EE) might protect against intrauterine growth retardation (IUGR)......

Effect of AnnexinA Group Translocated in Extracellular Vesicles on Tumorigenesis

期刊: CURRENT MOLECULAR MEDICINE, 2021; 21 (4)

Annexin, a calcium-dependent phospholipid-binding protein, can affect tumor cell adhesion, proliferation, apoptosis, invasion and metastasis, as well ......

Association of High-Mobility Group Box-1 with Inflammation-related Cytokines in the Aqueous Humor with Acute Primary Angle-Closure Eyes

期刊: CURRENT MOLECULAR MEDICINE, 2021; 21 (3)

Aim: The aim of this study was to measure the levels of High-mobility group box-1 (HMGB1) and inflammation-related cytokines in the aqueous humor of p......

Effects of Stearic Acid on Proliferation, Differentiation, Apoptosis, and Autophagy in Porcine Intestinal Epithelial Cells

期刊: CURRENT MOLECULAR MEDICINE, 2020; 20 (2)

Background: Stearic acid (SA), a saturated long-chain fatty acid consisting of 18 carbon atoms, is widely found in feed ingredients, such as corn, soy......

New Insights into Apolipoprotein A5 and the Modulation of Human Adipose-derived Mesenchymal Stem Cells Adipogenesis

期刊: CURRENT MOLECULAR MEDICINE, 2020; 20 (2)

Background: The hallmark of obesity is the excessive accumulation of triglyceride (TG) in adipose tissue. Apolipoprotein A5 (ApoA5) has been shown to ......

Cytochalasin D Promotes Osteogenic Differentiation of MC3T3-E1 Cells via p38-MAPK Signaling Pathway

期刊: CURRENT MOLECULAR MEDICINE, 2020; 20 (1)

Background: Bone defect caused by trauma, tumor resection, infection or congenital malformation is a common clinical disease. Bone tissue engineering ......

Involvement of Upregulated P53-Induced Death Domain Protein in Retinal Ganglion Cells Apoptosis After Optic Nerve Crush

期刊: CURRENT MOLECULAR MEDICINE, 2020; 20 (1)

Purpose: Retinal ganglion cells (RGCs) apoptosis is a common characteristic of optic neuropathies. p53-induced protein with a death domain (PIDD) is a......

Decrease in Serum Levels of Adiponectin and Increase in 8-OHdG: a Culprit for Cognitive Impairment in the Elderly Patients with Type 2 Diabetes

期刊: CURRENT MOLECULAR MEDICINE, 2020; 20 (1)

Background: Adiponectin and 8-Hydroxy-2'-deoxyguanosine (8-OHdG) are identified as important biomarkers in the pathogenesis process of type 2 diabetes......

Effects of Morphine on Interstitial Cells of Cajal in Rabbit Colon and Small Intestinal Transit: An Experimental Study

期刊: CURRENT MOLECULAR MEDICINE, 2020; 20 (3)

Objective: This study aims to investigate the effect of morphine with naloxone on intestinal peristalsis and the number of interstitial cells of Cajal......

Change in Quality of Life of OSAHS Patients with Minimally Invasive Surgery or CPAP Therapy: A 2-year Retrospective, Single-center Parallel-group Study

期刊: CURRENT MOLECULAR MEDICINE, 2020; 20 (3)

Background: By including untreated obstructive sleep apnea-hypopnea syndrome (OSAHS) patients as the control group, this study explores the influence ......

Use of Chou's 5-Steps Rule to Reveal Active Compound and Mechanism of Shuangshen Pingfei San on Idiopathic Pulmonary Fibrosis

期刊: CURRENT MOLECULAR MEDICINE, 2020; 20 (3)

Background: Shuangshen Pingfei San (SPS) is the derivative from the classic formula Renshen Pingfei San in treating idiopathic pulmonary fibrosis (IPF......

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