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Molecular mechanism and pharmacokinetics of flavonoids in the treatment of resistant EGF receptor-mutated non-small-cell lung cancer: A narrative review

期刊: BRITISH JOURNAL OF PHARMACOLOGY, 2021; 178 (6)

Here, we review the molecular mechanism and pharmacokinetics of flavonoids in the treatment of resistant EGF receptor (EGFR)-mutated non-small-cell lu......

Quercetin relieves D-amphetamine-induced manic-like behaviour through activating TREK-1 potassium channels in mice

期刊: BRITISH JOURNAL OF PHARMACOLOGY, 2021; 178 (18)

Background and Purpose Quercetin is a well-known plant flavonoid with neuroprotective properties. Earlier work suggested it may relieve psychiatric di......

Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis

期刊: BRITISH JOURNAL OF PHARMACOLOGY, 2021; 178 (17)

Background and Purpose Pyroptosis is a lytic form of pro-inflammatory cell death characterised as caspase 1 dependent with canonical NLRP3 inflammasom......

Exploiting D-2 receptor beta-arrestin2-biased signalling to suppress tumour growth of pituitary adenomas

期刊: BRITISH JOURNAL OF PHARMACOLOGY, 2021; 178 (17)

Background and Purpose Dopamine agonists targeting D-2 receptor have been used for decades in treating pituitary adenomas. There has been little clear......

Prelimbic cortical stimulation disrupts fear memory consolidation through ventral hippocampal dopamine D-2 receptors

期刊: BRITISH JOURNAL OF PHARMACOLOGY, 2021; 178 (17)

Background and Purpose Anxiety disorders pose one of the biggest threats to mental health worldwide, yet current therapeutics have been mostly ineffec......

Pathophysiological roles of cell surface and extracellular protein disulfide isomerase and their molecular mechanisms

期刊: BRITISH JOURNAL OF PHARMACOLOGY, 2021; 178 (15)

Protein disulfide isomerase (PDI) is the prototypic member of the thiol isomerase family that catalyses disulfide bond rearrangement. Initially identi......

Physalin B attenuates liver fibrosis via suppressing LAP2 alpha-HDAC1-mediated deacetylation of the transcription factor GLI1 and hepatic stellate cell activation

期刊: BRITISH JOURNAL OF PHARMACOLOGY, 2021; 178 (17)

Background and Purpose Liver fibrosis is one of the leading causes of morbidity and mortality worldwide but lacks any acceptable therapy. The transcri......

Hyperoxia-induced miR-342-5p down-regulation exacerbates neonatal bronchopulmonary dysplasia via the Raf1 regulator Spred3

期刊: BRITISH JOURNAL OF PHARMACOLOGY, 2021; 178 (11)

Background and Purpose Bronchopulmonary dysplasia (BPD) is the most prevalent chronic paediatric lung disease and is linked to the development of chro......

Cerebroprotection by dioscin after experimental subarachnoid haemorrhage via inhibiting NLRP3 inflammasome through SIRT1-dependent pathway

期刊: BRITISH JOURNAL OF PHARMACOLOGY, 2021; 178 (18)

Background and Purpose Dioscin has multiple biological activities and is beneficial for cardiovascular and cerebral vascular diseases. Here, we invest......

Scorpion venom heat-resistant synthesized peptide ameliorates 6-OHDA-induced neurotoxicity and neuroinflammation: likely role of Na(v)1.6 inhibition in microglia

期刊: BRITISH JOURNAL OF PHARMACOLOGY, 2021; 178 (17)

Background and Purpose: Microglia-related inflammation is associated with the pathology of Parkinson's disease. Functional voltage-gated sodium channe......

Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy

期刊: BRITISH JOURNAL OF PHARMACOLOGY, 2021; 178 (13)

Background and purpose PD-1/PD-L1 antibodies have achieved great success in clinical treatment. However, monoclonal antibody drugs also have challenge......

Anti-stress effects of combined block of glucocorticoid and mineralocorticoid receptors in the paraventricular nucleus of the hypothalamus

期刊: BRITISH JOURNAL OF PHARMACOLOGY, 2021; 178 (18)

Background and Purpose: Mineralocorticoid receptors (MRs), glucocorticoid receptors (GRs) and corticotropin-releasing factor (CRF) in the paraventricu......

The natural product trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer

期刊: BRITISH JOURNAL OF PHARMACOLOGY, 2021; 178 (12)

Background and Purpose Pancreatic cancer is an exceptionally fatal disease. However, therapeutic drugs for pancreatic cancer have presented a serious ......

Protopanaxadiol alleviates neuropathic pain by spinal microglial dynorphin A expression following glucocorticoid receptor activation

期刊: BRITISH JOURNAL OF PHARMACOLOGY, 2021; 178 (15)

Background and Purpose New remedies are required for the treatment of neuropathic pain due to insufficient efficacy of available therapies. This study......

Oxoglaucine mediates Ca2+ influx and activates autophagy to alleviate osteoarthritis through the TRPV5/calmodulin/CAMK-II pathway

期刊: BRITISH JOURNAL OF PHARMACOLOGY, 2021; 178 (15)

Background and Purpose: Stimulation of calcium influx and suppression of autophagy play important roles in the pathogenesis of osteoarthritis (OA). In......

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