期刊： JOURNAL OF EXPERIMENTAL MEDICINE, 2021; 218 (5)
Aging is a strong risk factor and an independent prognostic factor for progressive human idiopathic pulmonary fibrosis (IPF). Aged mice develop nonres......
期刊： JOURNAL OF EXPERIMENTAL MEDICINE, 2021; 218 (6)
Previous studies implicated the neuronal guidance molecule netrin-1 in attenuating myocardial ischemia-reperfusion injury. However, the tissue-specifi......
期刊： JOURNAL OF EXPERIMENTAL MEDICINE, 2021; 218 (6)
Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity, lipid peroxidation, and plasma membrane damage. The u......
期刊： JOURNAL OF EXPERIMENTAL MEDICINE, 2021; 218 (5)
Although widely used for their potent anti-inflammatory and immunosuppressive properties, the prescription of glucocorticoid analogues (e.g., dexameth......
期刊： JOURNAL OF EXPERIMENTAL MEDICINE, 2021; 218 (6)
Single-cell RNA sequencing is a powerful tool to examine cellular heterogeneity, novel markers and target genes, and therapeutic mechanisms in human c......
期刊： JOURNAL OF EXPERIMENTAL MEDICINE, 2021; 218 (6)
Activating beige adipocytes in white adipose tissue (WAT) to increase energy expenditure is a promising strategy to combat obesity. We identified that......
期刊： JOURNAL OF EXPERIMENTAL MEDICINE, 2021; 218 (7)
TGF beta is essential for the generation of anti-tumor Th9 cells; on the other hand, it causes resistance against anti-tumor immunity. Despite recent ......
期刊： JOURNAL OF EXPERIMENTAL MEDICINE, 2021; 218 (5)
The role of the PYHIN family member absent in melanoma 2 (AIM2), another important inflammasome sensor, in EAE remains unclear. In this study, we foun......
期刊： JOURNAL OF EXPERIMENTAL MEDICINE, 2021; 218 (5)
The oncogene DEK is found fused with the NUP214 gene creating oncoprotein DEK-NUP214 that induces acute myeloid leukemia (AML) in patients, and secret......
期刊： JOURNAL OF EXPERIMENTAL MEDICINE, 2021; 218 (6)
Recurrent and new tumors, attributed in part to lateral invasion, are frequent in squamous cell carcinomas and lead to poor survival. We identified a ......
期刊： JOURNAL OF EXPERIMENTAL MEDICINE, 2021; 218 (6)
Abdominal aortic aneurysms (AAAs) are a life-threatening disease for which there is a lack of effective therapy preventing aortic rupture. During AAA ......
期刊： JOURNAL OF EXPERIMENTAL MEDICINE, 2021; 218 (6)
Gastric cancer (GC) is one of the most common deadly cancers in the world. Although patient genomic data have identified AT-rich interaction domain 1A......
期刊： JOURNAL OF EXPERIMENTAL MEDICINE, 2021; 218 (3)
Expression of the signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is critical for the germinal center (GC) reaction and T ce......
期刊： JOURNAL OF EXPERIMENTAL MEDICINE, 2021; 218 (3)
Three papers by James Allison and Tasuku Honjo published in JEM between 1995 and 2000 crystallized seminal insights into the role of CTLA-4 and PD-1 i......
