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LncRNA HOTAIR promotes ?-synuclein aggregation and apoptosis of SH-SY5Y cells by regulating miR-221-3p in Parkinson?s disease

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 417 (1)

Parkinson's disease (PD) is a common neurodegenerative disease. Here, the purpose of the study was to explore the function of long non-coding RNA (lnc......

JIF:3.547

SIRT3-mediated deacetylation protects inner hair cell synapses in a H2O2-induced oxidative stress model in vitro

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 418 (2)

Oxidative stress is considered a driving event in the damage to inner hair cell (IHC) synapses. Mitochondrial deacetylase sirtuin 3 (SIRT3) is an impo......

JIF:3.547

CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 419 (1)

Cholesterol homeostasis plays an important role in the maintenance of normal body functions. CYP27A1 is a key enzyme known to regulate cholesterol hom......

JIF:3.547

Periodontal ligament fibroblasts-derived exosomes induced by PGE(2) inhibit human periodontal ligament stem cells osteogenic differentiation via activating miR-34c-5p/SATB2/ERK

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 419 (2)

Several studies have confirmed that exosomes containing microRNAs (miRNAs) from the aseptic inflammatory microenvironment play an important role in bo......

JIF:3.547

FOXO4 mediates resistance to oxidative stress in lens epithelial cells by modulating the TRIM25/Nrf2 signaling

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 420 (1)

Oxidative stress damage to the lens is a key factor in most cataracts. Forkhead box O 4 (FOXO4), a member of the forkhead box O family, plays a pivota......

JIF:3.547

Semaphorin 3E promote Schwann cell proliferation and migration

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 412 (2)

Schwann cells (SCs) play a critical role in peripheral nerve (PN) regeneration because of their ability to proliferate, migrate, and provide trophic s......

JIF:3.547

Silencing of circ-CDK14 suppresses osteosarcoma progression through the miR-198/E2F2 axis

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 414 (1)

Background: Osteosarcoma (OS) is the most common primary bone malignancy. Circular RNAs (circRNAs) have been implicated in OS pathogenesis. In the cur......

JIF:3.547

Downregulation of SHMT2 promotes the prostate cancer proliferation and metastasis by inducing epithelial-mesenchymal transition

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 415 (2)

Serine hydroxymethyltransferase 2 (SHMT2) is a key enzyme that regulates serine/glycine transition; however, its specific function and molecular mecha......

JIF:3.547

Prognostic and therapeutic significance of XPO1 in T-cell lymphoma

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 416 (2)

T-cell lymphoma (TCL) is a highly heterogeneous group of invasive non-Hodgkin lymphoma with adverse prognosis and limited treatment options. The relat......

JIF:3.547

Identification of a long noncoding RNA Gm17501 as a novel negative regulator of cardiac hypertrophy

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 418 (1)

Pathological cardiac hypertrophy is an independent risk factor for the development of heart failure. Long noncoding RNAs (lncRNAs), an emerging class ......

JIF:3.547

Pre-treatment with morphine prevents lipopolysaccharide-induced acute respiratory distress syndrome in rats via activation of opioid receptors

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 418 (1)

Purpose: Acute respiratory distress syndrome (ARDS), a severe medical condition, is among the major causes of death in critically ill patients. Morphi......

JIF:3.547

Angiotensin II-induced miR-31-5p upregulation promotes vascular smooth muscle cell proliferation and migration

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 419 (1)

Angiotensin II (Ang II) plays a central role in vascular smooth muscle cell (VSMC) proliferation and migration, being key to regulate vascular functio......

JIF:3.547

Catalpol modulating the crosstalking between mesenchymal stromal cells and macrophages via paracrine to enhance angiogenesis and osteogenesis

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 418 (2)

Due to the inflammatory responses associated with defect occurrence and materials implantation, immunoreg-ulation has emerged as a promising strategy ......

JIF:3.547

The transcript ENST00000444125 of lncRNA LINC01503 promotes cancer stem cell properties of glioblastoma cells via reducing FBXW1 mediated GLI2 degradation

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 412 (1)

LINC010503 is a novel oncogenic lncRNA in multiple cancers. In this study, we further explored the expression of LINC010503 transcripts and their regu......

JIF:3.547

LncRNA KCNQ1OT1 promotes osteogenic differentiation via miR-205-5p/RICTOR axis

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 415 (1)

Osteoporosis is a prevalent degenerative disease that is characterized by decreased bone density and strength, resulting in gradually increasing bone ......

JIF:3.547

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