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Precision medicine in IBD: genes, drugs, bugs and omics

期刊: NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2022; 19 (2)

Key studies published in 2021 demonstrated mechanisms that drive macrophage-fibroblast pathogenicity in Crohn's disease, developed multi-omics profile......

JIF:18.704

A single-cell atlas of fibroblasts: one size does not fit all

期刊: NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2021; 18 (9)

Delineation of fibroblast heterogeneity has the potential to identify select mesenchymal populations involved in health and disease. A recent study in......

Potential intestinal infection and faecal-oral transmission of SARS-CoV-2

期刊: NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, ; ()

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to more than 200 countries and regions globally. SARS-CoV-2 is thought to spre......

What are the clinical settings and outcomes of lean NAFLD?

期刊: NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, ; ()

The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased rapidly and is associated with obesity in epidemiology and pathogenesis. A ne......

COVID-19 and liver disease: mechanistic and clinical perspectives

期刊: NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, ; ()

This Review provides mechanistic and clinical insights into COVID-19 in the context of liver disease, discussing the potential underlying biology and ......

The day after COVID-19 in IBD: how to go back to 'normal'

期刊: NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2020; 17 (8)

During the coronavirus disease 2019 (COVID-19) pandemic, inflammatory bowel disease (IBD) practices have been disrupted. This Comment summarizes the k......

Joining the dots for better liver cancer treatment

期刊: NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2020; 17 (2)

Key advances Powerful single-cell analyses discover rare cellular sub-populations and complex cell-cell interactions at an unprecedented level, which ......

Organoid models of gastrointestinal cancers in basic and translational research

期刊: NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2020; 17 (4)

Organoid technology has emerged as a powerful method for studying gastrointestinal cancers. This Review describes organoid models of gastrointestinal ......

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