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Quaternary enteric solid dispersion prepared by hot-melt extrusion to mask the bitter taste and enhance drug stability

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021; 597 ()

To mask the bitterness of drug is profoundly important especially in children's medication. This study designed and investigated a quaternary enteric ......

Additives-directed lyotropic liquid crystals architecture: Simulations and experiments

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021; 600 ()

In this study, alkanes and sucrose esters are employed to investigate the influence of additives on lyotropic liquid crystal architecture. After molec......

Stimuli-responsive nanoparticles based on poly acrylic derivatives for tumor therapy

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021; 601 ()

Serve side effects caused by discriminate damage of chemotherapeutic drugs to normal cell and cancer cells remain a main obstacle in clinic. Hence, co......

Inositol hexanicotinate self-micelle solid dispersion is an efficient drug delivery system in the mouse model of non-alcoholic fatty liver disease

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021; 602 ()

Inositol hexanicotinate (IHN) self-micelle solid dispersion (SD) with glycyrrhizic acid (GA) and arabic gum (AG) was prepared by mechanical ball milli......

Nanodelivery of a self-assembling prodrug with exceptionally high drug loading potentiates chemotherapy efficacy

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021; 605 ()

Nanomedicines have achieved several successful clinical applications for cancer therapy over the past decades. To date, numerous nanomedicine formats ......

Co-amorphous systems of sinomenine with nonsteroidal anti-inflammatory drugs: A strategy for solubility improvement, sustained release, and drug combination therapy against rheumatoid arthritis

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021; 606 ()

Rheumatoid arthritis (RA) is a chronic autoimmune joint disorder that affects about 1% of the world population and may lead to severe disability and c......

Curcumin-loaded liposomes with the hepatic and lysosomal dual-targeted effects for therapy of hepatocellular carcinoma

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021; 602 ()

Curcumin can induce cancer cell apoptosis through lysosomal permeabilization pathway. However, the poor selectivity of curcumin restricts its use in t......

Van der Waals force-driven indomethacin-ss-paclitaxel nanodrugs for reversing multidrug resistance and enhancing NSCLC therapy

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021; 603 ()

The high expression of multidrug resistance-associated protein 1 (MRP1) in cancer cells caused serious multidrug resistance (MDR), which limited the e......

Solidification of volatile D-Limonene by cyclodextrin metal-organic framework for pulmonary delivery via dry powder inhalers: In vitro and in vivo evaluation

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021; 606 ()

D-Limonene (D-Lim), a volatile oil extracted from citrus fruits, has therapeutic effects on lung inflammation and cancer, whilst the deep delivery of ......

Potential of Raman spectroscopy in facilitating pharmaceutical formulations development - An AI perspective

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021; 597 ()

Drug development is time-consuming and inherently possesses a high failure rate. Pharmaceutical formulation development is the bridge that links a new......

Gelation process of carboxymethyl chitosan-zinc supramolecular hydrogel studied with fluorescence imaging and mathematical modelling

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021; 605 ()

Herein we report on a detailed study about the gelation kinetics of carboxymethyl chitosan-zinc (CMCh-Zn) supramolecular hydrogel by taking advantage ......

Topotecan-loaded thermosensitive nanocargo for tumor therapy: In vitro and in vivo analyses

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021; 606 ()

This study demonstrates the development of topotecan (TCN) loaded thermosensitive nanocargos (TCN-TS-NC) for intramuscular (IM) administration with en......

Co-delivery of antibiotic and baicalein by using different polymeric nanoparticle cargos with enhanced synergistic antibacterial activity

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021; 599 ()

To evaluate the effect of polymer structures on their unique characteristics and antibacterial activity, this study focused on developing amphiphilic ......

Accelerating transdermal delivery of insulin by ginsenoside nanoparticles with unique permeability

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021; 605 ()

Diabetes is a metabolic disease caused by insufficient insulin secretion, action or resistance, in which insulin plays an irreplaceable role in the it......

Electrospun fixed dose combination fibers for the treatment of cardiovascular disease

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021; 599 ()

Fixed dose combinations (FDCs) offer an accessible way to simplify complex therapeutic regimens by the simultaneous presentation of multiple drugs in ......

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