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Imaging with Ion Channels

期刊: ANALYTICAL CHEMISTRY, 2021; 93 (13)

We describe the incorporation of gated ion channels into probes for scanning ion conductance microscopy (SICM) as a robust platform for collecting spa......

Dual-Stimulus Responsive Near-Infrared Reversible Ratiometric Fluorescent and Photoacoustic Probe for In Vivo Tumor Imaging

期刊: ANALYTICAL CHEMISTRY, 2021; 93 (13)

Tumor-specific imaging is a major challenge in clinical tumor resection. To overcome this problem, several activatable probes have been developed for ......

Highly Sensitive and Specific Mass Spectrometric Platform for miRNA Detection Based on the Multiple-Metal-Nanoparticle Tagging Strategy

期刊: ANALYTICAL CHEMISTRY, 2021; 93 (14)

The multiple-metal-nanoparticle tagging strategy has generally been applied to the multiplexed detection of multiple analytes of interest such as micr......

DeepDigest: Prediction of Protein Proteolytic Digestion with Deep Learning

期刊: ANALYTICAL CHEMISTRY, 2021; 93 (15)

Proteolytic digestion of proteins by one or more proteases is a key step in shotgun proteomics, in which the proteolytic products, i.e., peptides, are......

Microscopic Afterglow Bioimaging by Ultralong Organic Phosphorescent Nanoparticles in Living Cells and Zebrafish

期刊: ANALYTICAL CHEMISTRY, 2021; 93 (16)

Compared with short-lived emission probes featuring fluorescence imaging, the use of phosphorescent probes imparts the advantage of long-lived signal ......

Anti-Tim4 Grafting Strongly Hydrophilic Metal-Organic Frameworks Immunoaffinity Flake for High-Efficiency Capture and Separation of Exosomes

期刊: ANALYTICAL CHEMISTRY, 2021; 93 (16)

Exosomes have become the most ideal analysis target for liquid biopsy since they carry a large amount of genetic materials. The study on exosomes has ......

Ag2S/Ag Nanoparticle Microelectrodes for In Vivo Potentiometric Measurement of Hydrogen Sulfide Dynamics in the Rat Brain

期刊: ANALYTICAL CHEMISTRY, 2021; 93 (18)

Hydrogen sulfide (H2S) plays a pivotal role in gas signal transduction, neuroprotection, and regulation of physiological and pathological processes. H......

Covalent Amide-Bonded Nanoflares for High-Fidelity Intracellular Sensing and Targeted Therapy: A Superstable Nanosystem Free of Nonspecific Interferences

期刊: ANALYTICAL CHEMISTRY, 2021; 93 (22)

A nanoflare, a conjugate of Au nanoparticles (NPs) and fluorescent nucleic acids, is believed to be a powerful nanoplatform for diagnosis and therapy.......

Tunable Dual-Effector Allostery System for Nucleic Acid Analysis with Enhanced Sensitivity and an Extended Dynamic Range

期刊: ANALYTICAL CHEMISTRY, 2021; 93 (23)

In the last few years, studies have demonstrated the existence of dual-effector allosteric cooperativity in nature and the mechanism underlying enhanc......

Combined Paper Centrifugal Chromatographic Separation and SERS Detection for Multicomponent Substances

期刊: ANALYTICAL CHEMISTRY, 2021; 93 (25)

The separation and chemical analysis of mixtures in an emergency situation represent major challenges, especially in remote or poverty-stricken areas.......

CRISPR-/Cas12a-Mediated Liposome-Amplified Strategy for the Surface-Enhanced Raman Scattering and Naked-Eye Detection of Nucleic Acid and Application to Food Authenticity Screening

期刊: ANALYTICAL CHEMISTRY, 2021; 93 (29)

Surface-enhanced Raman scattering (SERS) has been recognized as a powerful tool for biosensors due to the ultrahigh sensitivity and unique fingerprint......

Photoactivatable Red Chemiluminescent AIEgen Probe for In Vitro/Vivo Imaging Assay of Hydrazine

期刊: ANALYTICAL CHEMISTRY, 2021; 93 (30)

Here, we have developed a novel photoactivatable red chemiluminescent AIEgen probe (ACL), based on the combination of the red-emission AIEgen fluoroph......

Fabrication of Homochiral Metal-Organic Frameworks in TiO2 Nanochannels for In Situ Identification of 3,4-Dihydroxyphenylalanine Enantiomers

期刊: ANALYTICAL CHEMISTRY, 2021; 93 (33)

Enantioselective identification of chiral molecules is important for biomedical and pharmaceutical research. However, owing to identical molecular for......

Targeted Luminescent Probes for Precise Upconversion/NIR II Luminescence Diagnosis of Lung Adenocarcinoma

期刊: ANALYTICAL CHEMISTRY, 2021; 93 (11)

In this research, the antibody of the searched hub genes has been proposed to combine with a rare-earth composite for an upconversion luminescence (UC......

Plasmon-Enhanced Electroactivity of AuRu Nanostructures for Electroanalysis Applications

期刊: ANALYTICAL CHEMISTRY, 2021; 93 (11)

An electrochemical sensing interface is limited by poor reproducibility and inevitable interferences present in practical applications due to the weak......

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