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Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis

期刊: BIOMATERIALS, 2021; 271 ()

Pulmonary fibrosis is a rapidly progressive and fatal fibrotic lung disease with high mortality and morbidity. However, pulmonary fibrosis therapy in ......

NIR-II bioimaging of small organic molecule

期刊: BIOMATERIALS, 2021; 271 ()

In recent years, people have been actively exploring new imaging methods with high biological imaging performance because the clinical image definitio......

Physiologically triggered injectable red blood cell-based gel for tumor photoablation and enhanced cancer immunotherapy

期刊: BIOMATERIALS, 2021; 271 ()

Hydrogels are widely used for drug delivery and tissue engineering. Here we developed a simple injectable red blood cells (RBCs)-based gel for cancer ......

Hydrogel-based therapeutic angiogenesis: An alternative treatment strategy for critical limb ischemia

期刊: BIOMATERIALS, 2021; 274 ()

Critical limb ischemia (CLI) is the most severe clinical manifestation of peripheral arterial disease (PAD), resulting in the total or partial loss of......

Antibiotics armed neutrophils as a potential therapy for brain fungal infection caused by chemotherapy-induced neutropenia

期刊: BIOMATERIALS, 2021; 274 ()

Chemotherapy-induced neutropenia, a symptom of neutrophil depletion, makes cancer patients highly susceptible to invasive fungal infection with substa......

CCR2-engineered mesenchymal stromal cells accelerate diabetic wound healing by restoring immunological homeostasis

期刊: BIOMATERIALS, 2021; 275 ()

Impaired wound healing presents great health risks to patients. While encouraging, the current clinical successes of mesenchymal stromal cell (MSC)-ba......

Nitric oxide release activated near-Infrared photothermal agent for synergistic tumor treatment

期刊: BIOMATERIALS, 2021; 276 ()

Activatable phototherapeutic agents (PTA) in one system with synergistic gas therapy (GT) and photothermal therapy (PTT) hold great promise for highly......

Activation, development, and attenuation of modeling- and remodeling-based bone formation in adult rats

期刊: BIOMATERIALS, 2021; 276 ()

Activation of modeling-based bone formation (MBF -bone formation without prior activation of bone resorp-tion), has been identified as an important me......

Sequential activation of heterogeneous macrophage phenotypes is essential for biomaterials-induced bone regeneration

期刊: BIOMATERIALS, 2021; 276 ()

Macrophage has been gradually recognized as a central regulator in tissue regeneration, and the study of how macrophage mediates biomaterials-induced ......

Mutual-reinforcing sonodynamic therapy against Rheumatoid Arthritis based on sparfloxacin sonosensitizer doped concave-cubic rhodium nanozyme

期刊: BIOMATERIALS, 2021; 276 ()

Rheumatoid arthritis (RA) is an autoimmune disease associated with synovitis and cartilage destruction. Ultrasound (US)-driven sonodynamic therapy (SD......

Nanoengineered biomimetic Cu-based nanoparticles for multifunational and efficient tumor treatment

期刊: BIOMATERIALS, 2021; 276 ()

The microwave dynamic therapy (MDT) mediated by cytotoxic reactive oxygen species (ROS) is a promising anticancer therapeutic method. However, the the......

CO/chemosensitization/antiangiogenesis synergistic therapy with H2O2-responsive diselenide-containing polymer

期刊: BIOMATERIALS, 2021; 271 ()

Carbon monoxide (CO) therapy and antiangiogenesis therapy (AAT) are regarded as promising approaches for cancer treatment. However, the poor tumor tar......

4D spatiotemporal modulation of biomolecules distribution in anisotropic corrugated microwrinkles via electrically manipulated microcapsules within hierarchical hydrogel for spinal cord regeneration

期刊: BIOMATERIALS, 2021; 271 ()

Although traditional 3D scaffolds or biomimetic hydrogels have been used for tissue engineering and regenerative medicine, soft tissue microenvironmen......

Natural discoidal lipoproteins with tiny modification for tumor extracellular dissociation in antitumor chemoimmunotherapy

期刊: BIOMATERIALS, 2021; 275 ()

Appealing cancer immunotherapy requires synchronous presentation of tumor antigens and immunoadjuvant. Herein, a "one-step" modification strategy is p......

Mononuclear phagocyte system blockade using extracellular vesicles modified with CD47 on membrane surface for myocardial infarction reperfusion injury treatment

期刊: BIOMATERIALS, 2021; 275 ()

Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) with anti-apoptotic and anti-inflammatory properties have been intensively studied. H......

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