As we continue to find new regulatory roles for RNAs, a theme is emerging in which regulation may not be mediated through the actions of a specific RN......
In general, riboswitches functioning through a cotranscriptional kinetic trapping mechanism (kt-riboswitches) show higher switching efficiencies in re......
p53 protein is a key regulator of cellular homeostasis by coordinating the framework of antiproliferative pathways as a response to various stress fac......
The PIWI-interacting RNA (piRNA) pathway is a protection mechanism against transposons in animal germ cells. Most PIWI proteins possess piRNA-guided e......
The GIGYF proteins interact with 4EHP and RNA-associated proteins to elicit transcript-specific translational repression. However, the mechanism by wh......
The mammalian cell nucleus contains dozens of membrane-less nuclear bodies that play significant roles in various aspects of gene expression. Several ......
Under certain circumstances, any of the three termination codons can be read through by a near-cognate tRNA; i.e., a tRNA whose two out of three antic......
The characterization of the conformational landscape of the RNA backbone is rather complex due to the ability of RNA to assume a large variety of conf......
The SRP9/SRP14 heterodimer is a central component of signal recognition particle (SRP) RNA (7SL) processing and Alu retrotransposition. In this study,......
Removal of introns during pre-mRNA splicing, which is central to gene expression, initiates by base pairing of U1 snRNA with a 5' splice site (5'SS). ......
The design of new RNA sequences that retain the function of a model RNA structure is a challenge in bioinformatics because of the structural complexit......
Darwin's assertion that it is mere rubbish thinking, at present, of origin of life is no longer valid. By synthesizing origin of life (OoL) research f......
Neurons critically depend on regulated RNA localization and tight control of spatiotemporal gene expression to maintain their morphological and functi......
New methods for the global identification of RNA-protein interactions have led to greater recognition of the abundance and importance of RNA-binding p......
Small noncoding RNAs fulfill key functions in cellular and organismal biology, typically working in concert with RNA-binding proteins (RBPs). While pr......
