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肿瘤突变负荷应用于肺癌免疫治疗的专家共识

2021-11-20 中国临床肿瘤学会非小细胞肺癌专家委员会 中国肺癌杂志

肺癌

肺癌是全球范围内发病率和死亡率最高的恶性肿瘤之一。

中文标题：

肿瘤突变负荷应用于肺癌免疫治疗的专家共识

发布机构：

中国临床肿瘤学会非小细胞肺癌专家委员会

发布日期：

2021-11-20

简要介绍：

肺癌是全球范围内发病率和死亡率最高的恶性肿瘤之一。免疫检查点抑制剂(immune checkpoint inhibitors, ICIs),包括程序性死亡受体1(programmed cell death 1, PD-1)抗体、程序性死亡受体1配体(programmed cell death ligand 1, PD-L1)抗体和细胞毒性T淋巴细胞相关蛋白4(cytotoxic T lymphocyte antigen 4, CTLA-4)抗体,给部分晚期肺癌患者带来了显著的生存获益,改变了晚期肺癌的治疗格局。既往研究表明,PD-1/PD-L1抗体在晚期非小细胞肺癌(non-small cell lung cancer, NSCLC)中的客观缓解率只有20%左右。所以临床亟需可靠的生物标志物协助筛选ICIs潜在获益人群,提高治疗响应率。肿瘤突变负荷(tumor mutational burden, TMB)是除PD-L1表达以外新兴的免疫治疗标志物。肺癌中PD-L1表达与TMB的相关性不大,评估TMB可扩大免疫治疗的获益人群。然而在临床实践中,TMB的检测、阈值的确定和临床指导策略仍然没有形成规范。本共识将对TMB检测和应用场景给出指导性建议,以促进TMB在肺癌免疫治疗中应用的规范化。

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    2021-12-14 ms4000000559127129

    学习了，对临床有很好的指导意义

    0

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    2021-12-14 ms6210040651457422

    好

    0

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    2021-12-11 ms8000000249558528

    学习了

    0

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    2021-12-04 ms8000000973640961

    1

    0

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    2021-11-30 微探

    学习学习

    0

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