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Neurology:血液中神经丝蛋白轻链可以用于帕金森疾病的鉴别诊断吗?

2017-02-15 xing.T MedSci原创

由此可见,血液中NfL浓度定量可以用来区分PD和APD。在初级保健和专科诊所中,基于血液的NfL可能因此被列入具有帕金森病症状患者诊断检查。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在明确血液中神经丝蛋白轻链(NfL)是否与脑脊液中NfL一样具有同样的诊断效能来区分帕金森病(PD)和非典型帕金森障碍(APD),因此可以改善帕金森病的诊断方法。

该研究包含了3个独立的前瞻性队列:伦德伯格队列(n=278)和伦敦队列(n=117),由健康对照者和PD患者、进行性核上性麻痹(PSP)患者、皮质综合征(CBS)患者、多系统萎缩(MSA)患者组成,以及一个早期疾病队列(n=109),其包含了病程≤3年的PD、PSP、MSA或CBS患者。研究人员利用超灵敏的单分子阵列(Simoa)测量血液中的NfL浓度,并进一步评估了区分PD和APD的诊断准确性。

研究人员发现血液和CSF中NfL浓度之间存在很强的相关性(ρ≥0.73-0.84,P≤0.001)。在所有队列中,MSA、PSP和CBS患者(即所有APD组)血液中NfL浓度显著升高,相比于PD患者和健康对照者(P<0.001)。此外,在伦德伯格队列中,血液中NfL能准确地区分PD和APD(曲线下面积[AUC]为0.91);在伦敦队列(AUC为0.85)和早期疾病队列(AUC为0.81)中也得到了类似的结果。

由此可见,血液中NfL浓度定量可以用来区分PD和APD。在初级保健和专科诊所中,基于血液的NfL可能因此被列入具有帕金森病症状患者诊断检查。

原始出处:

Oskar Hansson,et al. Blood-based NfL A biomarker for differential diagnosis of parkinsonian disorder. Neurology.  http://dx.doi.org/10.1212/WNL.0000000000003680

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    2017-02-18 1e10c84am36(暂无匿称)

    文章真心不错耶

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=1999827, encodeId=c4be199982e02, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Apr 03 09:15:00 CST 2017, time=2017-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801647, encodeId=9124180164e09, content=<a href='/topic/show?id=91f1e4142bd' target=_blank style='color:#2F92EE;'>#神经丝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74142, encryptionId=91f1e4142bd, topicName=神经丝)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d01326, createdName=lizhou0204, createdTime=Fri Jan 12 20:15:00 CST 2018, time=2018-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033252, encodeId=8720203325259, content=<a href='/topic/show?id=e4d4e414363' target=_blank style='color:#2F92EE;'>#神经丝蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74143, encryptionId=e4d4e414363, topicName=神经丝蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Sun Jul 09 00:15:00 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019741, encodeId=3d7d2019e414e, content=<a href='/topic/show?id=e8d8e41458a' target=_blank style='color:#2F92EE;'>#神经丝蛋白轻链#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74145, encryptionId=e8d8e41458a, topicName=神经丝蛋白轻链)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=606c2500035, createdName=ms3153534357578991, createdTime=Mon Mar 13 01:15:00 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176757, encodeId=6c561e675702, content=文章真心不错耶, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Feb 18 09:47:23 CST 2017, time=2017-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406651, encodeId=19d9140665147, content=<a href='/topic/show?id=ae2e4851879' target=_blank style='color:#2F92EE;'>#帕金森疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48518, encryptionId=ae2e4851879, topicName=帕金森疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1f002566823, createdName=guguangxiang, createdTime=Fri Feb 17 12:15:00 CST 2017, time=2017-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506916, encodeId=584f150691622, content=<a href='/topic/show?id=a66b9624e0c' target=_blank style='color:#2F92EE;'>#鉴别诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96247, encryptionId=a66b9624e0c, topicName=鉴别诊断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77179846395, createdName=Homburg, createdTime=Fri Feb 17 12:15:00 CST 2017, time=2017-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176562, encodeId=1a791e656255, content=文章真心不错耶, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Feb 17 08:38:14 CST 2017, time=2017-02-17, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1999827, encodeId=c4be199982e02, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Apr 03 09:15:00 CST 2017, time=2017-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801647, encodeId=9124180164e09, content=<a href='/topic/show?id=91f1e4142bd' target=_blank style='color:#2F92EE;'>#神经丝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74142, encryptionId=91f1e4142bd, topicName=神经丝)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d01326, createdName=lizhou0204, createdTime=Fri Jan 12 20:15:00 CST 2018, time=2018-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033252, encodeId=8720203325259, content=<a href='/topic/show?id=e4d4e414363' target=_blank style='color:#2F92EE;'>#神经丝蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74143, encryptionId=e4d4e414363, topicName=神经丝蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Sun Jul 09 00:15:00 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019741, encodeId=3d7d2019e414e, content=<a href='/topic/show?id=e8d8e41458a' target=_blank style='color:#2F92EE;'>#神经丝蛋白轻链#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74145, encryptionId=e8d8e41458a, topicName=神经丝蛋白轻链)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=606c2500035, createdName=ms3153534357578991, createdTime=Mon Mar 13 01:15:00 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176757, encodeId=6c561e675702, content=文章真心不错耶, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Feb 18 09:47:23 CST 2017, time=2017-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406651, encodeId=19d9140665147, content=<a href='/topic/show?id=ae2e4851879' target=_blank style='color:#2F92EE;'>#帕金森疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48518, encryptionId=ae2e4851879, topicName=帕金森疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1f002566823, createdName=guguangxiang, createdTime=Fri Feb 17 12:15:00 CST 2017, time=2017-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506916, encodeId=584f150691622, content=<a href='/topic/show?id=a66b9624e0c' target=_blank style='color:#2F92EE;'>#鉴别诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96247, encryptionId=a66b9624e0c, topicName=鉴别诊断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77179846395, createdName=Homburg, createdTime=Fri Feb 17 12:15:00 CST 2017, time=2017-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176562, encodeId=1a791e656255, content=文章真心不错耶, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Feb 17 08:38:14 CST 2017, time=2017-02-17, status=1, ipAttribution=)]
    2017-02-17 1e10c84am36(暂无匿称)

    文章真心不错耶

    0

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