Ann Oncol：江泽飞等发现循环肿瘤细胞为中国乳腺癌患者生存独立预测因素

2013-07-18 ecoliDH5 dxy

在2013年7月14日在线出版的《肿瘤学年鉴》(Annals of Oncology)杂志上，发表了中国军事医学科学院江泽飞教授等人的一项研究成果，该项多中心、双盲、前瞻性研究针对中国转移性乳腺癌(MBC)女性患者，旨在评价循环肿瘤细胞(CTC)测定在预测抗癌治疗手段缓解率方面的潜在应用价值，其中包括人表皮生长因子受体-2(HER-2)靶向药物相关缓解情况、无进展生存期(PFS)以及总生存期(OS

在2013年7月14日在线出版的《肿瘤学年鉴》(Annals of Oncology)杂志上，发表了中国军事医学科学院江泽飞教授等人的一项研究成果，该项多中心、双盲、前瞻性研究针对中国转移性乳腺癌(MBC)女性患者，旨在评价循环肿瘤细胞(CTC)测定在预测抗癌治疗手段缓解率方面的潜在应用价值，其中包括人表皮生长因子受体-2(HER-2)靶向药物相关缓解情况、无进展生存期(PFS)以及总生存期(OS)。

在研究中，共有300例MBC患者计划完成3次CTC血样采集，并参与两项影像学研究。在6家中国前沿癌症中心所招募的300例MBC患者中，共有294例为可评价性患者。多变量Cox回归分析表明，基线CTC数目仍然为PFS ([风险比 (HR) = 1.93; 95% 置信区间(CI) = 1.39–2.69; P < 0.001)及OS (HR = 3.76; 95% CI = 2.35–6.01; P < 0.001)的独立预后因素。首次随访结果发现，也可得到PFS(P = 0.049)及OS (P < 0.001)的类似结果。

江教授等人认为，CTC计数可为中国MBC患者提供较为确切的预后信息，并可作为PFS与OS相关的独立因素。此外，该研究表明，对于包括HER-2阳性病情在内的各亚型疾病，无论治疗手段如何，CTC计数均具有预后价值。

Circulating tumor cells predict progression-free and overall survival in Chinese patients with metastatic breast cancer

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2015-10-18 hlycom3356

这篇文章写得很好

172 0
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2015-10-18 hlycom3356

这篇文章写得很好

161 0
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2015-10-18 hlycom3356

这篇文章写得很好

204 0
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2015-10-18 hlycom3356

这篇文章写得很好

158 0
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2015-02-28 xiaoai5777

不错的文章，学习了

159 0
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2014-02-17 jktdtl

#江泽飞#

91 0
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2014-06-25 minlingfeng

#Oncol#

64 0
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2014-02-11 tastas

#患者生存#

66 0
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2013-07-20 朱睿睿

#预测因素#

53 0
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2013-07-20 hmwwww

#肿瘤细胞#

48 0

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Ann Oncol：江泽飞等发现循环肿瘤细胞为中国乳腺癌患者生存独立预测因素

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