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Diabetes Care:体重过轻增加了2型糖尿病患者罹患终末期肾病的风险

2020-03-19 MedSci原创 MedSci原创

根据韩国人群的血糖状况和糖尿病病程,体重过轻与ESRD较高的HR有关。在研究期间,BMI维持稳定的组别中也存在这种关联。

2型糖尿病患者或非2型糖尿病患者肥胖与终末期肾病(ESRD)之间的关系存在争议。近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员根据韩国人群的血糖状况来评估BMI对ESRD风险的影响。

该研究在2009年对9969848名参与者进行了一次全民健康保险服务健康体检,从基线到ESRD诊断日期,随访期约为8.2年。根据世界卫生组织对亚洲人群的推荐标准,将人群肥胖程度进行分类,并且根据血糖水平分为以下5个类别:正常、空腹血糖受损(IFG)、新诊断糖尿病、糖尿病病程<5年和糖尿病病程≥5年。

所有参与者在调整所有协变量后,体重过轻与ESRD高风险相关。在IFG组、新诊断2型糖尿病组、糖尿病病程<5年和糖尿病病程≥5年组中,体重过轻的风险比(HR)随着血糖状况的恶化而增加(HR对于IFG患者为1.431;新诊断2型糖尿病患者为2.114;糖尿病病程<5年的患者为4.351;糖尿病病程≥5年的患者为6.397),以正常体重和正常空腹血糖为参照。不管是否存在2型糖尿病,在持续体重过轻个体中ESRD调整后的HR也是最高的(非糖尿病患者的HR为1.606,糖尿病患者的HR为2.14)。

由此可见,根据韩国人群的血糖状况和糖尿病病程,体重过轻与ESRD较高的HR有关。在研究期间,BMI维持稳定的组别中也存在这种关联。

原始出处:

Yang-Hyun Kim,et al.Underweight Increases the Risk of End-Stage Renal Diseases for Type 2 Diabetes in Korean Population: Data From the National Health Insurance Service Health Checkups 2009-2017.Diabetes Care.2020.https://doi.org/10.2337/dc19-2095

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    2020-10-17 zhaojie88
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1693499, encodeId=53ea169349935, content=<a href='/topic/show?id=7e2de81588c' target=_blank style='color:#2F92EE;'>#终末期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78158, encryptionId=7e2de81588c, topicName=终末期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f6429431807, createdName=anminleiryan, createdTime=Mon Aug 03 00:58:55 CST 2020, time=2020-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639400, encodeId=60191639400df, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Nov 13 01:58:55 CST 2020, time=2020-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761354, encodeId=8f1e1e61354a3, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Oct 17 20:58:55 CST 2020, time=2020-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1902404, encodeId=23c4190240434, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sat Oct 03 22:58:55 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383615, encodeId=c19713836154d, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Sat Mar 21 11:58:55 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474899, encodeId=0f1f14e489994, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sat Mar 21 11:58:55 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1476384, encodeId=5ab314e63845c, content=<a href='/topic/show?id=eb69e81665d' target=_blank style='color:#2F92EE;'>#终末期肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78166, encryptionId=eb69e81665d, topicName=终末期肾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fb27278676, createdName=zengjiayao, createdTime=Sat Mar 21 11:58:55 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043024, encodeId=d5b9104302444, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Mar 19 23:58:55 CST 2020, time=2020-03-19, status=1, ipAttribution=)]
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    2020-03-19 misszhang

    谢谢MedSci提供最新的资讯

    0

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