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Heart:动态血压和房颤长期风险!

2018-02-10 xing.T MedSci原创

由此可见,在基于人群的队列中,收缩期ABP是发生AF的重要预测因子。研究人员还观察到白天收缩压负荷>38%的参与者发生AF的风险显著增加。

关于动态血压(ABP)组分对房颤(AF)发生风险贡献的数据十分有限。近日,在心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员旨在前瞻性地检验这样一个假设,即在欧洲人群研究中,ABP可能是房颤发生发展的潜在危险因素。

研究人员记录了5个欧洲国家随机从普通人群中招募的3956名受试者白天血压(BP)。其中2776例(70.2%)参与者接受了完整的24小时ABP监测。中位随访时间为14年。研究人员将白天收缩压负荷定义为BP读数高于135mmHg的百分比。根据基线和随访时获得的心电图以及全科医生和/或医院的病历记录评估房颤的发生率。

总的来说,在58810人次每年的随访中,143名参与者发生了新发房颤。在校正后的Cox模型中,基线24h、白天和夜间收缩压水平每增加1个标准差发生AF的风险增加分别为27%(P=0.0056)、22%(P=0.023)和20%(P=0.029)。常规收缩压与房颤发生风险有关(18%; P=0.06)。与平均人群危险度相比,日间收缩压负荷位于最低四分位(<3%)参与者发生AF的风险降低了51%(P=0.0038),而最高四分位数(>38%),风险增加了46%(P=0.0094)。

由此可见,在基于人群的队列中,收缩期ABP是发生AF的重要预测因子。研究人员还观察到白天收缩压负荷>38%的参与者发生AF的风险显著增加。

原始出处:

Valérie Tikhonoff,et al. Ambulatory blood pressure and long-term risk for atrial fibrillation. Heart. 2018. http://dx.doi.org/10.1136/heartjnl-2017-312488

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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    2018-02-12 zhaojie88
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    2018-02-12 slcumt
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    2018-02-10 1e0f8808m18(暂无匿称)

    好文章.学习了.

    0

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