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JCEM：雌激素诱导甲状腺乳头状癌细胞的自噬

2015-04-29 沐晴 译 MedSci原创

雌激素甲状腺乳头状癌自噬
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甲状腺乳头状癌（PTC）的发生率在性别中的比例是女：男（1:3），关于性别差异的风险因素知之甚少。越来越多的研究认为雌激素在甲状腺肿瘤的发生中起重要作用，但是相关的机制并不清楚。近来有研究发现雌激素受体α（ER-α）可通过刺激活性氧的生成和胞外信号调节激酶诱导PTC的自噬。 研究者分析了ER-α在PTC患者甲状腺组织中的表达。通过化学和基因技术抑制PTC细胞自噬，检测PTC细胞的活力、增殖和

甲状腺乳头状癌（PTC）的发生率在性别中的比例是女：男（1:3），关于性别差异的风险因素知之甚少。越来越多的研究认为雌激素在甲状腺肿瘤的发生中起重要作用，但是相关的机制并不清楚。近来有研究发现雌激素受体α（ER-α）可通过刺激活性氧的生成和胞外信号调节激酶诱导PTC的自噬。


研究者分析了ER-α在PTC患者甲状腺组织中的表达。通过化学和基因技术抑制PTC细胞自噬，检测PTC细胞的活力、增殖和凋亡情况。对PTC细胞系BCPAP中的ER-α和自噬水平都进行了检测。




结果显示，与邻近的非肿瘤组织相比，ER-α的表达在PTC组织中升高了。雌激素以一种ER-α依赖的方式诱导PTC细胞自噬。通过ER/ ER-α诱导的自噬与活性氧的生成、细胞外信号调节激酶（ERK1/2）以及PTC细胞的存活/增长比例相关。化学性或基因敲出技术抑制自噬可以显著的抑制肿瘤细胞存活，并且促进其凋亡，进一步明确自噬在PTC进展中的积极作用。

最后，研究者认为ER-α可以通过提高PTC细胞自噬水平，促进PTC细胞生长。抑制PTC细胞自噬，可能成为一种治疗ER-α阳性的PTC新方法。

原始出处：

Fan D, Liu SY, van Hasselt CA,et al.Estrogen Receptor α Induces Prosurvival Autophagy in Papillary Thyroid Cancer via Stimulating Reactive Oxygen Species and Extracellular Signal Regulated Kinases. J Clin Endocrinol Metab. 2015 Apr;100(4):E561-71. doi: 10.1210/jc.2014-3257.

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    2015-09-28 achengzhao

    #JCE#

    0

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    2015-08-18 jianjun66

    #乳头状#

    0

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    2015-07-20 smallant2015

    #JCEM#

    0

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    2015-05-01 yxch36

    #癌细胞#

    0

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    2015-05-01 yzh399

    #甲状腺乳头状癌#

    0

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