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Radiology：氧增强MRI肾癌低氧图的价值

2018-08-07 shaosai MedSci原创

氧增强MR肾癌低氧
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本研究旨在验证T1加权氧增强（OE）MRI评价肿瘤低氧耗指标，评价该技术应用于临床的可能性，将结果发表在radiology上。

本研究旨在验证T1加权氧增强（OE）MRI评价肿瘤低氧耗指标，评价该技术应用于临床的可能性，将结果发表在radiology上。

本研究共纳入了临床前9例786-0-R肾细胞肾癌（RCC）异种移植模型和回顾性分析了8例RCC患者。测量吸入100%氧气后纵向弛豫率变化( ∆R1)，该值反应了由于氧分子出现引起组织质子顺磁效应。测量横向弛豫率(R2*)和氧气诱导的R2*变化( ∆R2*)，该值反映了脱氧血红蛋白的生成。利用中位数和基于体素值比较 ∆R1与R2*、 ∆R2*值。利用动态增强MRI灌注得到的肿瘤区域在OE MRI灌注区域和非灌注区域进行鉴别。利用方差分析比较每部分肿瘤亚灌注区域的 ∆R1 R2* 和 ∆R2*。

本研究表明，基于肿瘤和体素的 ∆R1、 ∆R2*比较并无显着相关性。在异种移植分析中表明，灌注Oxy-R要明显快于R2* (102.4 sec-1 vs 81.7 sec-1)，与灌注Oxy-E和非灌注区域比较要高于阴性？R2* (-22.9 sec-1 vs -5.4 sec-1) (P < .001)。在人类肿瘤中也有类似发现(P < .001)。此外，灌注Oxy-R有助于识别肿瘤低耗氧区，这也在病理中证实。

本研究表明，内在磁敏感指标验证OE MRI指标灌注Oxy-R。在异种移植模型和人类肿瘤中具有与病理相关性，因此有望应用于临床。

原始出处：

Little RA， Jamin Y， Boult JKR. et al.Mapping Hypoxia in Renal Carcinoma with Oxygen-enhanced MRI： Comparison with Intrinsic Susceptibility MRI and Pathology.Radiology.DOI：10.1148/radiol.2018171531

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    2018-08-07 1237a7a1m07暂无昵称

    新技术啊

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=337159, encodeId=65eb33e15972, content=新技术啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9e3b2411969, createdName=1237a7a1m07暂无昵称, createdTime=Tue Aug 07 21:35:18 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336994, encodeId=04e6336994dc, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Aug 07 08:10:39 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336957, encodeId=8a0e33695e56, content=学习了，谢谢分享！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7e71713450, createdName=太阳系小猪, createdTime=Tue Aug 07 06:52:20 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336951, encodeId=4b5a336951b2, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Tue Aug 07 06:11:22 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336945, encodeId=9832336945eb, content=学习学习再学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Aug 07 05:40:37 CST 2018, time=2018-08-07, status=1, ipAttribution=)]
    2018-08-07 龙胆草

    学习谢谢分享

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=337159, encodeId=65eb33e15972, content=新技术啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9e3b2411969, createdName=1237a7a1m07暂无昵称, createdTime=Tue Aug 07 21:35:18 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336994, encodeId=04e6336994dc, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Aug 07 08:10:39 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336957, encodeId=8a0e33695e56, content=学习了，谢谢分享！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7e71713450, createdName=太阳系小猪, createdTime=Tue Aug 07 06:52:20 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336951, encodeId=4b5a336951b2, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Tue Aug 07 06:11:22 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336945, encodeId=9832336945eb, content=学习学习再学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Aug 07 05:40:37 CST 2018, time=2018-08-07, status=1, ipAttribution=)]
    2018-08-07 太阳系小猪

    学习了，谢谢分享！！

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=337159, encodeId=65eb33e15972, content=新技术啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9e3b2411969, createdName=1237a7a1m07暂无昵称, createdTime=Tue Aug 07 21:35:18 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336994, encodeId=04e6336994dc, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Aug 07 08:10:39 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336957, encodeId=8a0e33695e56, content=学习了，谢谢分享！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7e71713450, createdName=太阳系小猪, createdTime=Tue Aug 07 06:52:20 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336951, encodeId=4b5a336951b2, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Tue Aug 07 06:11:22 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336945, encodeId=9832336945eb, content=学习学习再学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Aug 07 05:40:37 CST 2018, time=2018-08-07, status=1, ipAttribution=)]
    2018-08-07 1e1c07bdm01(暂无匿称)

    好

    0

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    2018-08-07 yjs木玉

    学习学习再学习

    0

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