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Hypertension:NfL(神经纤维丝轻链)可作为子娴前期诱导的神经损伤的血液标志物

2018-04-27 MedSci MedSci原创

现已证实子娴前期与之后的大脑结构和认知功能改变相关。Nf(神经纤维丝)是神经元的一种特殊的支架蛋白,其血清学定量检测可作为神经轴突损伤的生物标志物。Katrina Suzanne Evers等人在Basel大学医院进行了一前瞻性、纵向、单中心的研究,以确定有高子娴前期风险或子娴前期早期症状的单胎妊娠女性的血清Nf浓度。招募妊娠21周的孕妇,随访至分娩。197位孕妇有60位(30.5%)罹患子娴前期

现已证实子娴前期与之后的大脑结构和认知功能改变相关。Nf(神经纤维丝)是神经元的一种特殊的支架蛋白,其血清学定量检测可作为神经轴突损伤的生物标志物。

Katrina Suzanne Evers等人在Basel大学医院进行了一前瞻性、纵向、单中心的研究,以确定有高子娴前期风险或子娴前期早期症状的单胎妊娠女性的血清Nf浓度。招募妊娠21周的孕妇,随访至分娩。197位孕妇有60位(30.5%)罹患子娴前期。除了已知的的子娴前期标志物sFlt-1(可溶性fms样酪氨酸激酶-1)和PIGF(胎盘生长因子),还采用高灵敏的单分子阵列(Simoa)检测NfL(Nf轻链)。

NfL最重要的独立预测因子是母体年龄、妊娠次数和蛋白尿。在妊娠期间,NfL水平升高,而且在子娴前期孕妇中升高更明显。NfL、PIGF和sFlt-1在进行特征曲线分析的个体中的辨别精确度分别为0.68、0.81和0.84,对于36岁以上女性则分别是0.7、0.62和0.79。

总而言之,轴突损伤血清标志物NfL增加可预测子娴前期,特别是在大龄孕妇中,精确度与已知的血管生成因子相近。NfL或许可作为子娴前期诱导的大脑结构改变的早期标志物,有助于对该疾病进行分层管理

原始出处:

Katrina Suzanne Evers,et al.Neurofilament as Neuronal Injury Blood Marker in Preeclampsia.Hypertension. April
23,2018.https://doi.org/10.1161/HYPERTENSIONAHA.117.10314

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    2019-01-02 feather89
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  5. 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  6. 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  7. 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topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu Mar 14 13:37:00 CST 2019, time=2019-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804452, encodeId=9edf180445243, content=<a href='/topic/show?id=1a6ee7225e2' target=_blank style='color:#2F92EE;'>#纤维丝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77225, encryptionId=1a6ee7225e2, topicName=纤维丝)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Thu Dec 20 09:37:00 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397528, encodeId=e410139e528df, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Apr 29 08:37:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454832, encodeId=790b145483201, content=<a href='/topic/show?id=ca5f12e51d4' target=_blank style='color:#2F92EE;'>#NFL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12751, encryptionId=ca5f12e51d4, topicName=NFL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=90805606164, createdName=xiaoyeshuang, createdTime=Sun Apr 29 08:37:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489754, encodeId=1f131489e5423, content=<a href='/topic/show?id=5293e447259' target=_blank style='color:#2F92EE;'>#神经纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74472, encryptionId=5293e447259, topicName=神经纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53f28597470, createdName=stfoxst, createdTime=Sun Apr 29 08:37:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501284, encodeId=be77150128434, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sun Apr 29 08:37:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584285, encodeId=3ad8158428535, content=<a href='/topic/show?id=ee6de4320c6' target=_blank style='color:#2F92EE;'>#神经损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74320, encryptionId=ee6de4320c6, topicName=神经损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=771e17042997, createdName=LShY0906_98743849, createdTime=Sun Apr 29 08:37:00 CST 2018, time=2018-04-29, status=1, ipAttribution=)]
    2018-04-29 xiaoyeshuang
  8. [GetPortalCommentsPageByObjectIdResponse(id=2038891, encodeId=47bb2038891d3, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Wed Mar 27 00:37:00 CST 2019, time=2019-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727262, encodeId=58d21e272629b, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Jan 02 19:37:00 CST 2019, time=2019-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022427, encodeId=e911202242ed5, content=<a href='/topic/show?id=019845133cd' target=_blank style='color:#2F92EE;'>#子娴前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45133, encryptionId=019845133cd, topicName=子娴前期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3ad2500191, createdName=12498dd9m11暂无昵称, createdTime=Fri Jun 22 11:37:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841225, encodeId=64971841225e0, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu Mar 14 13:37:00 CST 2019, time=2019-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804452, encodeId=9edf180445243, content=<a href='/topic/show?id=1a6ee7225e2' target=_blank style='color:#2F92EE;'>#纤维丝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77225, encryptionId=1a6ee7225e2, topicName=纤维丝)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Thu Dec 20 09:37:00 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397528, encodeId=e410139e528df, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Apr 29 08:37:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454832, encodeId=790b145483201, content=<a href='/topic/show?id=ca5f12e51d4' target=_blank style='color:#2F92EE;'>#NFL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12751, encryptionId=ca5f12e51d4, topicName=NFL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=90805606164, createdName=xiaoyeshuang, createdTime=Sun Apr 29 08:37:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489754, encodeId=1f131489e5423, content=<a href='/topic/show?id=5293e447259' target=_blank style='color:#2F92EE;'>#神经纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74472, encryptionId=5293e447259, topicName=神经纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53f28597470, createdName=stfoxst, createdTime=Sun Apr 29 08:37:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501284, encodeId=be77150128434, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sun Apr 29 08:37:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584285, encodeId=3ad8158428535, content=<a href='/topic/show?id=ee6de4320c6' target=_blank style='color:#2F92EE;'>#神经损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74320, encryptionId=ee6de4320c6, topicName=神经损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=771e17042997, createdName=LShY0906_98743849, createdTime=Sun Apr 29 08:37:00 CST 2018, time=2018-04-29, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=2038891, encodeId=47bb2038891d3, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Wed Mar 27 00:37:00 CST 2019, time=2019-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727262, encodeId=58d21e272629b, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  10. [GetPortalCommentsPageByObjectIdResponse(id=2038891, encodeId=47bb2038891d3, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Wed Mar 27 00:37:00 CST 2019, time=2019-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727262, encodeId=58d21e272629b, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, 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