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Neurology:心肺适能改变多基因风险评分对AD生物标志物的影响

2017-03-26 xing.T MedSci原创

在中年人群中,CRF减弱了遗传易感性对CSF生物标志物的不利影响。这些研究结果支持这一概念,即增加心肺适能可能对那些AD遗传风险增加的患者是有益的。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章。研究人员旨在评估来自于APOE4、CLU和ABCA7的多遗传风险评分(PRS)是否与脑脊液中阿尔茨海默病(AD)病理学生物标记相关,以及较高的心肺适能(CRF)是否可以调整PRS与脑脊液生物标志物之间的相关性。

在这个横断面分析研究中共纳入了95例来自于威斯康星阿尔茨海默氏病预防注册试验的参与者。他们根据基因型分为APOE4、CLU和ABCA7,并且计算每一位参与者的PRS。参与者进行了腰穿脑脊液采集。β-淀粉样蛋白42(Aβ42)、Aβ40、总tau(T-tau)和磷酸化的tau蛋白(p-tau)进行定量免疫测定,以及计算Aβ42/Aβ40和tau/β42比值。研究人员从纳入了性别、年龄、体重指数、静息心率以及自我报告体力活动的验证方程中估计了CRF。采用协变量调整后的回归分析来评估PRS和脑脊液生物标志物之间的相关性。此外,将PRS×CRF术语纳入模型中,研究人员评估了这些相关性是否会被CRF进行调整。

较高的PRS与较低的Aβ42/Aβ40(P<0.001)、较高的T-tau/β42(P=0.012)和较高的p-tau/Aβ42(P=0.040)比值相关。此外,研究人员观察到PRS×CRF与Aβ42/Aβ40(P=0.003)、T-tau/β42(P=0.003)和p-tau/Aβ42(P=0.001)存在相互作用。具体来说,PRS和脑脊液生物标志物之间的相关性在那些较高CRF的患者有所减弱。

在中年人群中,CRF减弱了遗传易感性对CSF生物标志物的不利影响。这些研究结果支持这一概念,即增加心肺适能可能对那些AD遗传风险增加的患者是有益的。

原始出处:

Stephanie A. Schultz,et al. Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD. Neurology. 2017. http://www.neurology.org/content/early/2017/03/24/WNL.0000000000003862.short

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    2017-10-24 aids222
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createdTime=Tue Mar 28 06:08:00 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560595, encodeId=7b1f15605958f, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Tue Mar 28 06:08:00 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-07-31 syscxl
  5. [GetPortalCommentsPageByObjectIdResponse(id=1949761, encodeId=5d541949e61b5, content=<a href='/topic/show?id=b1ec431e5ab' target=_blank style='color:#2F92EE;'>#多基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43175, encryptionId=b1ec431e5ab, topicName=多基因风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Tue Dec 26 03:08:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704493, encodeId=cb071e04493bd, content=<a href='/topic/show?id=1f5b41931ce' target=_blank style='color:#2F92EE;'>#基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41931, encryptionId=1f5b41931ce, topicName=基因风险)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdTime=Tue Mar 28 06:08:00 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560595, encodeId=7b1f15605958f, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Tue Mar 28 06:08:00 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2018-01-26 yinhl1978
  6. [GetPortalCommentsPageByObjectIdResponse(id=1949761, encodeId=5d541949e61b5, content=<a href='/topic/show?id=b1ec431e5ab' target=_blank style='color:#2F92EE;'>#多基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43175, encryptionId=b1ec431e5ab, topicName=多基因风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Tue Dec 26 03:08:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704493, encodeId=cb071e04493bd, content=<a href='/topic/show?id=1f5b41931ce' target=_blank style='color:#2F92EE;'>#基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41931, encryptionId=1f5b41931ce, topicName=基因风险)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  7. 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  8. 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createdTime=Tue Mar 28 06:08:00 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560595, encodeId=7b1f15605958f, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Tue Mar 28 06:08:00 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-03-28 1e10c84am36(暂无匿称)

    文章不错,值得分享

    0

  9. 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