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J Clin Gastro: 早期使用结肠镜检查不会增加下消化道出血的危险性

2018-09-02 MedSci MedSci原创

有关下消化道出血(LGIB)的患者早期行结肠镜检查是否会增加30天死亡率目前还没有定论,内镜干预造成的额外需要输血的数据十分有限。本研究的主要目标是确定LGIB的早期结肠镜检查是否与患者30天死亡率降低相关。

背景:
有关下消化道出血(LGIB)的患者早期行结肠镜检查是否会增加30天死亡率目前还没有定论,内镜干预造成的额外需要输血的数据十分有限。本研究的主要目标是确定LGIB的早期结肠镜检查是否与患者30天死亡率降低相关。

方法:
研究人眼使用机器学习算法识别在2008年1月至2015年9月期间住院的患有LGIB的患者。入院第2天进行结肠镜检查定义为早期结肠镜检查,第3天和第5天之间进行结肠镜检查定义为晚期结肠镜检查。使用合理的混杂因素构建早期结肠镜检查的倾向评分。使用单变量和多变量逻辑回归来分析30天死亡率,内镜干预和输血需求相关的因素。

结果:
共有1204名患者接受了LGIB结肠镜检查。其中,295名患者(25%)接受了早期结肠镜检查,这些患者的Charlson合并症指数较低(P= 0.001),住院时间较短(3 VS 5 d,P= 0.0001)。早期结肠镜检查与30天死亡率降低无关[(OR):0.73;95%(CI),0.27-1.69],但与内镜干预增加(OR:2.62; CI,1.37-4.95)和输血需求减少有关(OR:0.65; CI,0.49-0.87)。

结论:
早期结肠镜检查不会影响患者30天内死亡率,因此临床工作中医生应该允许更早的内镜干预。

原始出处:

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    2019-02-03 爆笑小医
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    2018-09-22 许安
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    2018-09-04 zhouqu_8
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